基本信息

    姓名:
    王华楠
    职称:
    教授  博士生导师  硕士生导师
    性别:
    毕业院校:
    荷兰莱德堡大学
    学位:
    博士
    在职信息:
    在职                          
    所在单位:
    生物工程学院
    学科:
    生物工程 
    办公地点:
    大连理工大学生物工程学院525
                
      

     
团队简介

课题组介绍

人体组织器官修复重建是目前临床医学的重大需求,需要结合生物学、材料学、工程学等多学科的交叉来实现。组织工程和再生医学的诞生和发展,为实现人体组织和器官修复再生带来了曙光。该技术结合材料学、医学、生物学和工程学的理论和技术,以人工合成生物材料作为细胞组织再生的模板,结合具有具有分化成不同器官潜能的多能干细胞和诱导干细胞分化的生物活性信号因子,构建工程化的组织体以实现对组织和器官的修复和重建。

王华楠教授课题组面向再生医学相关的重大科学和技术难题,研究工作主要围绕水凝胶生物材料研发、细胞微环境研究、微流控芯片技术和3D生物打印技术等生物制造技术等领域,探索人体组织器官修复重建的解决方案,并为再生医学相关研究的临床转化不断努力。

 

    课题组长

王华楠,工学、医学博士,教授、博士生导师,中组部海外高层次引进人才,荷兰Rubicon青年学者、辽宁省“百千万人才计划”百人、辽宁省“兴辽英才计划”青年拔尖人才,生物材料学会增材制造分会委员、血液净化分会委员。主要从事生物医用材料和再生医学领域的研究工作,研究工作主要围绕水凝胶生物材料研发、微流控芯片技术、3D生物打印技术、细胞微环境研究等领域,并在生物材料临床转化方面做出创新成果。先后承担包括重点研发计划课题和自然科学基金等省部级科研项目8项。已在Nature Materials,Advanced Materials,Biomaterials,Tissue Engineering等重要期刊上发表学术论文50余篇,撰写专著和著作章节4篇,论文被引用次数超过2500+次,h-index=24;授权国际、国内专利8项,公开专利申请20余项,多项专利成功转化,并开发出3款三类医疗器械耗材产品正在进入临床试验阶段。

 

    研究方向描述

1 水凝胶生物材料研发

生物材料是组织工程技术实现人体组织修复再生的基础和关键。传统的将生物材料、生物活性因子以及干细胞简单复合的组织工程技术已经被证实难以成功诱导组织再生,因此开发结构和功能更加复杂化、可精准调控材料性能的新型生物材料已经成为研究热点。本课题组的研究工作重点研发具有更精细微观结构、更可控材料参数、更精准微环境仿生调控、更适于微创化方式应用的新型生物活性材料,研发微纳米胶体材料的制备技术和自下而上构建整体材料的构建方法,进一步基于相关基础研究开发水凝胶材料在组织修复重建、创伤修复、骨软骨修复、3D生物打印等生物医学领域的应用。相关研究已申请和授权多项国际、国内专利,并获得成功转化,已开发出3款三类医疗器械耗材产品正在进入临床试验阶段。

2 生物制造技术研发

组织/器官体外生物制造是以生物材料、活性因子和细胞等构成的生物墨水为材料,利用数字化建模、生物打印、体外培养等技术制造出力学、结构、功能与自然组织相似的活性结构体,长期来看是解决人体组织器官巨大移植需求的根本途径,在短期内可用于体外精确构建微组织/微生理模型从而为药物评价提供高效的工具,是先进制造的前沿。本课题组基于在生物医用材料研发和细胞微环境研究的工作基础,围绕3D打印技术和微流控芯片微加工工艺的研发,开发用于微组织模块和仿生类组织构建的生物制造技术,为人体组织器官的体外构建和功能转化提供新的解决方案。

3 细胞微环境研究

在活体组织内,干细胞处于复杂的、动态的、由细胞外基质(Extracellular Matrix, ECM)、信号因子以及相邻细胞共同组成的干细胞微环境(Stem cell niche)中,这一微型环境通过生化和物理信号调控干细胞贴附、迁移、增殖、分化等的行为和功能。大量研究证实生化信号(如生长因子、激酶、小分子、ECM化学组成等)对干细胞行为起着决定性作用,而我们对物理信号(如硬度、几何形状、拓扑结构等)调控干细胞命运的的认识仍很有限。本课题组利用材料学、组织工程学、生物力学、医学、计算机科学等多交叉学科技术,开展基于人体组织生理、病理状态下的生物力学微环境研究,构建组织工程与周围组织相互作用的研究平台和模型,研究细胞微环境条件的多功能多特征调控干细胞和免疫细胞行为,为实现具有生理功能的工程化人体组织器官重建建立基础。






 

 



代表性成果

科研项目

1.辽宁省“兴辽英才计划”青年拔尖人才项目,课题负责人,王华楠,2020-2023

2.科技部重点研发计划“功能化生物活性组织/器官体外精准制造基础”项目课题“微环境可控凝胶类生物墨水研发”2018YFA0703001,课题负责人,王华楠,2019-2023

3.国家自然科学基金委:面上项目(No.31870957):基于自修复胶体凝胶的干细胞力学微环境研究。主持人,王华楠,2019-2022

4.第十三批国家“千人计划”青年项目;主持人,王华楠,2017-2020

5.大连理工大学学科建设经费 No. DUT15RC (3)113;主持人,王华楠,2017-2020

6.国家自然科学基金委:青年基金项目(No.51503208):高强度、自修复纳米结构胶体凝胶的研发和组织工程应用。主持人,王华楠,2016-2018

7.荷兰科技部(NWO):Rubicon海外青年学者研究基金(No. 82512018);Self-assembly of cell-binding choline phosphate-functionalized gelatin microspheres and cells for bottom-up fabrication of 3D microstructured cellular constructs。 主持人,王华楠,2013-2015


              奖励和表彰

辽宁省“百千万人才工程”百人层次

第十三批中组部海外高层次引进人才

荷兰Rubicon海外青年学者

荷兰生物医学与组织工程学会(NBTE)最佳博士论文 (每两年评一名)

全国优秀博士学位论文提名

四川省优秀博士学位论文

Biomaterials杂志Top 50最高引用率奖


   代表工作














 



专利情况

1.王华楠,陈楷文,一种组织粘合用的高拉伸,高粘性,自愈合双网络水凝胶及其制备方法和应用。发明专利申请号:2019103855019.

2.王华楠,陈楷文,一种双网络结构复合水凝胶及其制备方法与应用。发明专利申请号:2019110764442.

3.王华楠,陈楷文,一种基于胶体颗粒-iPRF双网络结构的可注射、高强度复合水凝胶及其制备方法和应用。发明专利申请号:2019110764777.

4.王华楠,一种微流控装置及利用该装置制备微凝胶的方法,授权发明专利2016101501726,2016-3-16.

5.王华楠,一种用于制备微凝胶的微流控装置,授权实用新型专利2016202075098 .

6.王华楠,由有机/无机微米或纳米颗粒组装的、高强度、自修复、可注射复合胶体凝胶材料及其制备方法和应用,授权发明专利2016101650576 2016-3-22.

7.王华楠,由有机/无机微米或纳米颗粒组装的、高强度、自修复、可注射复合胶体凝胶材料及其制备方法和应用,发明专利申请2018114598396

8.王华楠,一种可注射型自愈合止血材料及其制备方法和应用,授权发明专利2017103351840.

9.王华楠,可用于药物加载和释放的可注射型自愈合凝胶及其制备方法和应用,发明专利2017103351836.

10.Stefanie Utech, Radivoje Prodanovic, Esther Amstad, Raluca Ostafe, David A. Weitz, Angelo S. Mao, David J. Mooney, Connie Chang Wilking, Huanan Wang. MICROPARTICLES, METHODS FOR THEIR PREPARATION AND USE.授权国际发明专利WO2015069634 A1, 2015-5-14.

11.王华楠,一种用于制备微凝胶的微流控装置,授权实用新型专利ZL201620207509.8.

12.王华楠,一种基于微流芯片装置的明胶纳米微粒的连续制备方法,发明专利,申请号201710601159.

13.王华楠,一种磷酸钙/明胶复合材料纳米颗粒的制备方法及其应用,发明专利,授权专利号201710600152.

14.王华楠,一种无机纳米颗粒-明胶核壳结构复合材料颗粒的制备方法,授权发明专利201710600536.0.

15.王华楠,一种用于连续制备明胶纳米微粒的微流控芯片装置,授权实用新型201720890702.0.

16.王华楠,张丽媛,一步法连续制备海藻酸钙微凝胶的微流控技术,发明专利申请号2017111152976



论文情况

 1. Fei Shao, Lei Yu, Yang Zhang, Chuanfeng An, Haoyue Zhang, Yujie Zhang, Yi Xiong and Huanan Wang* . Microfluidic encapsulation of single cells by alginate microgels using a trigger-gellified strategy. Front. Bioeng. Biotechnol. 2020,  doi: 10.3389/fbioe.2020.583065

2. Hua Ma, Kaiwen Chen, Bo Song, Zhixin Tang, Yundi Huang, Ting Zhang, Huanan Wang, Wenping Sun, Jingli Yuan. A visible-light-excitable mitochondria-targeted europium complex probe for hypochlorous acid and its application to time-gated luminescence bioimaging, 2020, Biosensors and Bioelectronics; 112560; 2020/8/26

3. Yafan Wan, Jianmei Han, Fang Cheng, Xinglong Wang, Huanan Wang, Qiling Song, Wei He. Green Preparation of Hierarchically Structured Hemostatic Epoxy-Amine Sponge. Chemical Engineering Journal, 2020, 125445, 2020/5/18

4. Chuanfeng An, Weijian Liu, Yang Zhang, Bo Pang, Hui Liu, Yujie Zhang, Haoyue Zhang, Liyuan Zhang, Hongbing Liao, Changle Ren*, Huanan Wang *. Continuous microfluidic encapsulation of single mesenchymal stem cells using alginate microgels as injectable fillers for bone regeneration. Acta Biomaterialia. DOI: 10.1016/j.actbio.2020.05.024

5. Zhumei Zhuang1‡, Yang Zhang2,3‡, Shengnan Sun1, Qiao Li4, Kaiwen Chen1, Chuanfeng An1, Libin Wang1, Jeroen JJP van den Beucken3, Huanan Wang1*. Control of matrix stiffness using methacrylate-gelatin hydrogels for macrophage-mediated inflammatory response, ACS Biomaterials Science & Engineering, 2020, 6, 5, 3091–3102

6. Zhixiang Mu, Kaiwen Chen, Shuai Yuan, Yihan Li, Yuanding Huang, Chao Wang, Yang Zhang, Wenzhao Liu, Wenping Luo, Panpan Liang, Xiaodong Li, Jinlin Song, Ping Ji, Fang Cheng, Huanan Wang*, Tao Chen*, Gelatin Nanoparticle-injectable Platelet-Rich Fibrin Double Network Hydrogels with Local Adaptability and Bioactivity for Enhanced Osteogenesis. Advanced Healthcare Materials. DOI: 10.1002/adhm.201901469

7. Yonghao Luo, Huanan Wang, Zihui Li, Xuyue Wang, Gengqiao Xie. Morphology investigation of sectional stripes and adhering slag based on vapor-to-melt ratio in Nd:YAG laser cutting of Al2O3 ceramics. Journal of Laser Applications 2019, 31, 032014

8. Kaiwen Chen, Yangyingfan Feng, Yang Zhang, Lei Yu, Xingxing Hao, Fei Shao, Zhenzhen Dou, Chuanfeng An, Zhumei Zhuang,Yonghao Luo, Yi Wang, Jinrong Wu, Ping Ji, Tao Chen*, Huanan Wang*, Entanglement-Driven Adhesion, Self-healing and High Stretchability of Double-Network PEG-Based Hydrogels. ACS Applied Materials & Interfaces 2019, 11, 40, 36458-36468 (IF=8.46)

9. Liyuan Zhang, Kaiwen Chen, Haoyue Zhang, Bo Pang, Chang-Hyung Choi, Angelo S. Mao, Hongbing Liao, Stefanie Utech, David J. Mooney, Huanan Wang*, David A. Weitz*; Microfluidic Templated Multi-compartment Microgels for 3D Encapsulation and Paring of Single Cells; Small, 2018, 14, 1702955.IF=10.94

10. Yi Wang, Zhenxing Cao, Jinrong Wu, Changshu Ma, Cuibo Qiu, Yachao Zhao, Fei Shao, Huanan Wang, Jing Zheng, Guangsu Huang. "Mechanically robust, ultrastretchable and thermal conducting composite hydrogel and its biomedical applications." Chemical Engineering Journal 360 (2019): 231-242.

11. Dize Li, Kaiwen Chen, Lian Duan, Tiwei Fu, Jiao Li, Si Wang, Qin Zou, Li Chen, Yangyingfan Feng, Huanan Wang, Tao Chen*, Strontium Ranelate Incorporated Enzyme-Cross-Linked Gelatin Nanoparticle/Silk Fibroin Aerogel for Osteogenesis in OVX-Induced Osteoporosis. ACS Biomaterials Science & Engineering, 2019, 5 (3), 1440-1451.IF=4.12

12. Mani Diba#, Huanan Wang#, Thomas E. Kodger, Shima Parsa, Sander C. G. Leeuwenburgh. Highly Elastic and Self‐Healing Composite Colloidal Gels. Advanced Materials. 2017, 29, 1604672

13. Angelo S. Mao, Jae-Won Shin, Steffi Utech, Huanan Wang, Oktay Uzun, David A. Weitz, David J. Mooney. Deterministic encapsulation of single cells in thin tunable microgels for niche modeling and therapeutic delivery. Nature Materials. 2017;16 (2) :236-243

14. Hu Y, Mao AS, Desai RM, Wang H, Weitz DA, Mooney DJ. Controlled self-assembly of alginate microgels by rapidly binding molecule pairs. Lab Chip. 2017;17 (14) :2481-2490. (IF=6.12)

15. Xu, Zhongbin; Huang, Xing; Wang, Pengfei*; Ruan, Xiaodong; Wang, Huanan*. Numerical Simulation of a Flow-based Microfluidic Gradient Generator. Microfluidics and Nanofluidics, 2016. 20: 89. (共同通讯作者) (IF=2.537)

16. Chang-Hyung Choi,# Huanan Wang,#,* Hyomin Lee, June Hwan Kim, Liyuan Zhang, Angelo Mao, David J. Mooney, David A. Weitz*. One-step generation of cell-laden microgels using double emulsion drops with a sacrificial ultra-thin oil shell. Lab on a Chip. 2016, 16, 1549–1555. IF=6.12 (共同一作,共同通讯)

17. Mani Diba#, Huanan Wang#, Thomas E. Kodger, Shima Parsa, and Sander C. G. Leeuwenburgh*. Highly Elastic and Self-Healing Composite Colloidal Gels. Advanced Materials. 2017.  DOI: 10.1002/adma.201604672.

 
     18. Huanan Wang, Matilde Bongio, Kambiz Farbod, Arnold WG Nijhuis, Jeroen van den Beucken, Otto C Boerman, Jan van Hest, Yubao Li, John A Jansen, Sander CG Leeuwenburgh, Development of injectable organic/inorganic colloidal composite gels made of self-assembling gelatin nanospheres and calcium phosphate nanocrystals. Acta Biomaterialia, 2014.1,10 (1), 508-519. SCI000329893300050, IF:6.191 (5.684)他引2JCR: Q1(ENGINEERING, BIOMEDICAL)

 

19.Huanan Wang, Q. Zou, O.C. Boerman, Y. Li, J.A. Jansen, S.C.G. Leeuwenburgh, Combined delivery of BMP-2 and bFGF from nanostructured colloidal gelatin gels and its effect on bone regeneration in vivo. Journal of Controlled Release, 2013.3, 166 (2), 172-181. SCI000316464800010,IF: 7.768 (7.261)他引24次,JCR: Q1 (PHARMACOLOGY & PHARMACY)

20. J. van der Stok*, Huana Wang* (*共同第一作者), S. A. Yavari, M. Siebelt, M. Sandker, J.H. Waarsing, H. Jahr, A.A. Zadpoor, S.C.G. Leeuwenburgh, H. Weinans, Bone regeneration in critical-sized defects using growth factor-loaded nanostructured colloidal gelatin gels incorporated into porous titanium scaffolds, Tissue Engineering Part A. 2013. 19 (23-24), 2605-2614. SCI000328333700008, IF: 5.444 (4.254)他引15次,JCR: Q2 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

21. Huanan Wang, O.C. Boerman, Y. Li, J.A. Jansen, S.C.G. Leeuwenburgh, Comparison of micro- vs nano-structured colloidal gelatin gels as injectable delivery vehicles for osteogenic proteins-bone morphogenetic proteins-2 and alkaline phosphatases, Biomaterials, 2012. 33: 8695-8703. SCI000310401000047, IF: 8.911, (8.312)他引20次,JCR: Q1 (MATERIALS SCIENCE, BIOMATERIALS)

22. Huanan Wang, S.C.G. Leeuwenburgh, Y. Li, J.A. Jansen, The use of micro- and nanospheres as functional components for bone tissue regeneration, Tissue Engineering Part B: Reviews, 2012, 18(1): 24-39. SCI000299601500003, IF: 5.444 (4.254)他引34次,JCR: Q2 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

23. Huanan Wang, M.B. Hansen, D.W.P.M. Löwik, J.C.M.v. Hest, Y. Li, J.A. Jansen, S.C.G. Leeuwenburgh, Oppositely charged gelatin nanospheres as building blocks for injectable and biodegradable gels Advanced Materials 2011. 23(12): H119-124.

MaterialsViews Nanowerk重点报道, link:

24. Huanan Wang, Y. Zuo, Q. Zou, L. Cheng, D. Huang, L. Wang, Y. Li, Nano-hydroxyapatite/ polyamide66 composite tissue-engineering scaffolds with anisotropy in morphology and mechanical behaviors, Journal of Polymer Science Part A: Polymer Chemistry, 2009, 47(3):658-669. SCI000262931800014, IF: 3.242, (3.245)他引20次,JCR:Q2 (POLYMER SCIENCE)

25. Huanan Wang, Y. Li, Y. Zuo, J. Li, S. Ma, L. Cheng, Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering, Biomaterials, 2007;28:3338–3348. SCI000247045600008, IF: 8.911 (8.312)他引306, JCR: Q1 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

Biomaterials杂志评为Top 50最高引用率奖

26. Huanan Wang, Y. Li, Y. Zuo, L. Cheng, Y. Wang, H. Li. Nano-hydroxyapatite/polymer composite scaffold for bone tissue engineering, Key Engineering Materials, 2007.330-332:365-368. (SCI000245026800090他引0)

27.王华楠,李玉宝,左奕,程琳,王园园,石浦江. 骨组织工程用n-HA/PA66多孔贯通支架的制备及表征;高分子材料科学与工程,2007; 23(1):230-233. (EI收录,他引次数:5)

28. Xin Zhao, Shen Liu, Lara Yildirimer, Hong Zhao, Ruihua Ding, Huanan Wang, Wenguo Cui,* David Weitz,* Injectable Stem Cell-Laden Photocrosslinkable Microspheres Fabricated Using Microfluidics for Rapid Generation of Osteogenic Tissue Constructs. Advanced Functional Materials. 2016, 26, 17, 2809–2819.

29. Ji W, Huanan Wang, JJJP. van den Beucken, F. Yang, XF. Walboomers, S. Leeuwenburgh, J.A. Jansen. Local delivery of small and large biomolecules in craniomaxillofacial bone, Advanced Drug Delivery Reviews. 2012, 64 (12), 1152-1164. SCI000308626800009, IF: 15.271 (12.707)他引9 次,JCRQ1 (PHARMACOLOGY & PHARMACY)

30. Michelle T Poldervaart, Huanan Wang, Johan van der Stok, Harrie Weinans, Sander CG Leeuwenburgh, F Cumhur Öner, Wouter JA Dhert, Jacqueline Alblas, Sustained release of BMP-2 in bioprinted alginate for osteogenicity in mice and rats, PloS One, 2013, 8 (8), e72610. SCI000323425700181, IF: 4.015 (3.533)他引8次,JCR: Q3 (MULTIDISCIPLINARY SCIENCES)

31. Yi Deng, Huanan Wang, Li Zhang, Yubao Li, Shicheng Wei. In situ synthesis and in vitro biocompatibility of needle-like nano-hydroxyapatite in agar–gelatin co-hydrogel. Materials Letters. 2013; 104:8-12. SCI000320142500003IF: 2.288 (2.269)引:6次,JCR: Q2MATERIALS SCIENCE, MULTIDISCIPLINARY)

32. R.P. Félix Lanao, K. Sariibrahimoglu, Huanan Wang, Joop GC Wolke, John A Jansen, Sander CG Leeuwenburgh, Accelerated Calcium Phosphate Cement Degradation Due to Incorporation of Glucono-Delta-Lactone Microparticles, Tissue Engineering Part A, 2013, 20 (1-2), 378-388. SCI000337280600035, IF: 5.444 (4.254)引用:2次,JCR: Q2 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

32. S.C.G. Leeuwenburgh, J. Jo, Huanan Wang, M. Yamamoto, J.A. Jansen, Y. Tabata, Mineralization, biodegradation, and drug release behavior of gelatin/apatite composite microspheres for bone regeneration, Biomacromolecules, 2010.11(10):2653-2659. SCI000282840200015, IF: 6.034 (5.788)他引19 , JCR: Q2BIOCHEMISTRY & MOLECULAR BIOLOGY)

33. M Zhao, J Li, Y Li, J Wang, Y Zuo, J Jiang, H Wang, Gradient Control of the Adhesive Force between Ti/TiO2 Nanotubular Arrays Fabricated by Anodization, Scientific reports, 2014. 4. doi:10.1038/srep07178, SCI000346184200007, IF:因子: 5.078 (5.078)引用:0次,JCR: Q2 (MULTIDISCIPLINARY SCIENCES)

34. H Jiang, Y Zuo, Q Zou, Huanan Wang, J Du, Y Li, X Yang, Biomimetic Spiral-Cylindrical Scaffold Based on Hybrid Chitosan/Cellulose/Nano-Hydroxyapatite Membrane for Bone Regeneration, 2013, ACS applied materials & interfaces, 2013, 5 (22), 12036-12044. SCI: 000327812300075, IF: 5.908 (5.9)引用:5次,JCR: Q1 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

35. H Jiang, Y Zuo, L Cheng, Huanan Wang, A Gu, Y Li. A homogenous CS/NaCMC/n-HA polyelectrolyte complex membrane prepared by gradual electrostatic assembling. Journal of Materials Science: Materials in Medicine. 2011. 22 (2), 289-297. SCI: 000288458700011, IF: 2.741 (2.379)他引4次,JCR: Q2 (ENGINEERING, BIOMEDICAL)

36. L Cheng, Y Zuo, Q Zou, J Li, Huanan Wang, J Shen, H Jiang, L Wang, Y Li, Effect of vanillin on the miscibility of poly (vinyl alcohol)/gelatin composite hydrogel: Physical and chemical properties, Journal of Applied Polymer Science, 2010, 117 (6), 3687-3693. SCI000279958200076IF: 1.635 (1.64),他引:3次,JCR: Q4(POLYMER SCIENCE)

37. J. Liao, L. Zhang, Y. Zuo, Huanan Wang, J. Li, Q. Zou, Y. Li, Development of nano-hydroxyapatite/polycarbonate composite for bone repair, Journal of Biomaterials Applications, 2009, 24:31-45. SCI000267377900003, IF: 2.752 (2.764),他引19次,JCR: Q2 (MATERIALS SCIENCE, BIOMATERIALS)

38. J. Li, Y. Zuo, X Cheng, W Yang, Huanan Wang, Y. Li, Preparation and characterization of nano-hydroxyapatite/polyamide 66 composite GBR membrane with asymmetric porous structure, Journal of Materials ScienceMaterials in Medicine, 2009, 20:1031-8. SCI000264837700004, IF: 2.741 (2.379),他引:23 次,JCR: Q2 (ENGINEERING, BIOMEDICAL)

39. K. Liu, Y. Li, F. Xu, Y. Zuo, L. Zhang, Huanan Wang, J. Liao, Graphite/poly (vinyl alcohol) hydrogel composite as porous ringy skirt for artificial cornea, Materials Science and Engineering: C, 2009.29(1): 261-266. SCI: 000262136700042, IF: 3.076 (2.736)他引:20次, JCR: Q2 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

40. X. Cheng, Y. Li, Y. Zuo, L. Zhang, J. Li, Huanan Wang, Properties and in vitro biological evaluation of nano-hydroxyapatite/chitosan membranes for bone guided regeneration, Materials Science and Engineering: C, 2009. 29(1), 29-35. SCI: 000262136700006, 000262136700006 IF: 3.076 (2.409),他引:31次,JCR: Q2 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

41. L Cheng, Y Li, Y Zuo, J Li, Huanan Wang, Nano-hydroxyapatite/polyamide 6 scaffold as potential tissue engineered bone substitutes, Materials Research Innovations, 2008.12:192-9. SCI: 000262710500009, IF: 0.491 (0.473),他引:6次,JCR: Q4 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

42. G. Zhou, Y. Li, L. Zhang, H. Li, M. Wang, L. Cheng, Y. Wang, Huanan Wang, P. Shi, The study of tri-phasic interactions in nano-hydroxyapatite/konjac glucomannan/chitosan composite, Journal of Materials Science. 2007, 42(8), 2591-2597. SCI000245431200010, IF: 2.303 (2.305),他引:13次,JCR:Q2 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

43. Xiang, HZ; Li, YB; Mu, YH; Wang, XJ; Hunan Wang, Li, H. Preparation and characterization of n-HA/PA66/CS biocomposite, Key Engineering Materials, 2007, 330-332 (1-2):463-466. (SCI000245026800114他引0)

44. L. Cheng, YB Li, Y Zuo, G Zhou, Huanan Wang, MB Wang, Preparation of Nano-Hydroxyapatite/Polyamide6 Composite Porous Scaffold for Bone Tissue Engineering, Materials science forum. 2007, 544, 793-796. (SCI000246224300198他引0)

45. YY Wang, YB Li, Y Zuo, Huanan Wang, L Cheng, G Zhou. The Influence of Preparation Condition on Nano-Hydroxyapatite Prepared in Different Solvent, Materials Science Forum. 2007. 544, 897. (SCI000246224300224他引0)

46. PJ Shi, YB Li, L Zhang, Y Zuo, M Wu, Huanan Wang, Fabrication of n-HA/CS Porous Scaffold Carrying Ampicillin-Loaded Microspheres, Materials Science Forum, 2007, 544, 941. (SCI000246224300235他引1)

47. YY Wang, YB Li, Y Zuo, HN Wang, L Cheng, G Zhou; Manufacturing Using a More Environmentally Friendly Process as well as Biomaterials-The Influence of Preparation Condition on Nano-Hydroxyapatite Prepared in Different Solvent; Materials Science Forum 544, 897

48. Z Gang, L Yubao, Z Li, L Hong, W Mingbo, C Lin, W Yuanyuan, Wang Huanan; The study of tri-phasic interactions in nano-hydroxyapatite/konjac glucomannan/chitosan composite. Journal of Materials Science 42 (8), 2591-2597

49. Zuo, Y; Li, YB; Zhang, X; Yang, WH; Li, JD; Mo, LR; Huanan Wang, Effect of compatibilizers on the properties of nano-hydroxyapatite reinforced polyamide 66 and high density polyethylene blends, Materials Science Forum, 2006, 510-511 : 978-981. (SCI000237176000245他引0)

50. Q ZOU, L ZHANG, Y ZUO, H WANG, Y LI, X LI; Characterization and cytocompatibility of nano-hydroxyapatite/chitosan bone cement consisting of astragalus polysaccharides; Journal of Functional Materials 9, 028

51. D HUANG, J LI, Y ZUO, Q ZOU, H WANG, Y LI; Fabrication and property of nano-hydroxyapatite/polyamide66 scaffolds modified with chitosan; Journal of Functional Materials 7, 034

 



著作情况

1. Huanan Wang. Nanostructured Colloidal Gelatin Gels for Bone Tissue Regeneration. 2013. pp1-219. Uitgeverij BOXPress, Oisterwijk. Nijmegen, the Netherlands. (著作)

2. Huanan Wang, S.C.G. Leeuwenburgh, Y. Li, J.A. Jansen. Micro- and Nanospheres for Tissue Engineering. Book chapter in handbook of “Micro and Nanotechnologies in Engineering Stem cells and Tissues”, 2013. 202-219. Wiley-IEEE press. (著作章节)

3. Jingrong Wu, Liheng Cai, Huanan Wang*. Advanced Materials for Self-healing Applications. Book chapter in "Design, Fabrication, Properties and Applications of Smart and Advanced Materials", 2014 . p308-341. CRC Press. (通讯作者)(著作章节)

4. M Diba, H Wang, S Leeuwenburgh; Development of self healing gels based on reversible cohesive interaction between self-assembling organic and inorganic nanoparticles; Self Healing Materials: Pioneering Research in the Netherlands, 37.(著作章节)

 



团队成员
带头人
  • 带头人
  • 教授
    副教授
    讲师
    联系方式

    王华楠 博士 教授

    办公地点:大连理工大学生物工程学院525室

    E-mail:huananwang@

    Tel:+86-411-84708083