基本信息

    姓名:
    王华楠
    职称:
    教授  博士生导师  硕士生导师
    性别:
    毕业院校:
    荷兰莱德堡大学
    学位:
    博士
    在职信息:
    在职                          
    所在单位:
    生物工程学院
    学科:
    生物工程 
    办公地点:
    大连理工大学生物工程学院525
                
      

     
团队简介
代表性成果
专利情况

1.王华楠,陈楷文,一种组织粘合用的高拉伸,高粘性,自愈合双网络水凝胶及其制备方法和应用。发明专利申请号:2019103855019.

2.王华楠,陈楷文,一种双网络结构复合水凝胶及其制备方法与应用。发明专利申请号:2019110764442.

3.王华楠,陈楷文,一种基于胶体颗粒-iPRF双网络结构的可注射、高强度复合水凝胶及其制备方法和应用。发明专利申请号:2019110764777.

4.王华楠,一种微流控装置及利用该装置制备微凝胶的方法,授权发明专利2016101501726,2016-3-16.

5.王华楠,一种用于制备微凝胶的微流控装置,授权实用新型专利2016202075098 .

6.王华楠,由有机/无机微米或纳米颗粒组装的、高强度、自修复、可注射复合胶体凝胶材料及其制备方法和应用,授权发明专利2016101650576 2016-3-22.

7.王华楠,由有机/无机微米或纳米颗粒组装的、高强度、自修复、可注射复合胶体凝胶材料及其制备方法和应用,发明专利申请2018114598396

8.王华楠,一种可注射型自愈合止血材料及其制备方法和应用,授权发明专利2017103351840.

9.王华楠,可用于药物加载和释放的可注射型自愈合凝胶及其制备方法和应用,发明专利2017103351836.

10.Stefanie Utech, Radivoje Prodanovic, Esther Amstad, Raluca Ostafe, David A. Weitz, Angelo S. Mao, David J. Mooney, Connie Chang Wilking, Huanan Wang. MICROPARTICLES, METHODS FOR THEIR PREPARATION AND USE.授权国际发明专利WO2015069634 A1, 2015-5-14.

11.王华楠,一种用于制备微凝胶的微流控装置,授权实用新型专利ZL201620207509.8.

12.王华楠,一种基于微流芯片装置的明胶纳米微粒的连续制备方法,发明专利,申请号201710601159.

13.王华楠,一种磷酸钙/明胶复合材料纳米颗粒的制备方法及其应用,发明专利,授权专利号201710600152.

14.王华楠,一种无机纳米颗粒-明胶核壳结构复合材料颗粒的制备方法,授权发明专利201710600536.0.

15.王华楠,一种用于连续制备明胶纳米微粒的微流控芯片装置,授权实用新型201720890702.0.

16.王华楠,张丽媛,一步法连续制备海藻酸钙微凝胶的微流控技术,发明专利申请号2017111152976



论文情况

 1. Fei Shao, Lei Yu, Yang Zhang, Chuanfeng An, Haoyue Zhang, Yujie Zhang, Yi Xiong and Huanan Wang* . Microfluidic encapsulation of single cells by alginate microgels using a trigger-gellified strategy. Front. Bioeng. Biotechnol. 2020,  doi: 10.3389/fbioe.2020.583065

2. Hua Ma, Kaiwen Chen, Bo Song, Zhixin Tang, Yundi Huang, Ting Zhang, Huanan Wang, Wenping Sun, Jingli Yuan. A visible-light-excitable mitochondria-targeted europium complex probe for hypochlorous acid and its application to time-gated luminescence bioimaging, 2020, Biosensors and Bioelectronics; 112560; 2020/8/26

3. Yafan Wan, Jianmei Han, Fang Cheng, Xinglong Wang, Huanan Wang, Qiling Song, Wei He. Green Preparation of Hierarchically Structured Hemostatic Epoxy-Amine Sponge. Chemical Engineering Journal, 2020, 125445, 2020/5/18

4. Chuanfeng An, Weijian Liu, Yang Zhang, Bo Pang, Hui Liu, Yujie Zhang, Haoyue Zhang, Liyuan Zhang, Hongbing Liao, Changle Ren*, Huanan Wang *. Continuous microfluidic encapsulation of single mesenchymal stem cells using alginate microgels as injectable fillers for bone regeneration. Acta Biomaterialia. DOI: 10.1016/j.actbio.2020.05.024

5. Zhumei Zhuang1‡, Yang Zhang2,3‡, Shengnan Sun1, Qiao Li4, Kaiwen Chen1, Chuanfeng An1, Libin Wang1, Jeroen JJP van den Beucken3, Huanan Wang1*. Control of matrix stiffness using methacrylate-gelatin hydrogels for macrophage-mediated inflammatory response, ACS Biomaterials Science & Engineering, 2020, 6, 5, 3091–3102

6. Zhixiang Mu, Kaiwen Chen, Shuai Yuan, Yihan Li, Yuanding Huang, Chao Wang, Yang Zhang, Wenzhao Liu, Wenping Luo, Panpan Liang, Xiaodong Li, Jinlin Song, Ping Ji, Fang Cheng, Huanan Wang*, Tao Chen*, Gelatin Nanoparticle-injectable Platelet-Rich Fibrin Double Network Hydrogels with Local Adaptability and Bioactivity for Enhanced Osteogenesis. Advanced Healthcare Materials. DOI: 10.1002/adhm.201901469

7. Yonghao Luo, Huanan Wang, Zihui Li, Xuyue Wang, Gengqiao Xie. Morphology investigation of sectional stripes and adhering slag based on vapor-to-melt ratio in Nd:YAG laser cutting of Al2O3 ceramics. Journal of Laser Applications 2019, 31, 032014

8. Kaiwen Chen, Yangyingfan Feng, Yang Zhang, Lei Yu, Xingxing Hao, Fei Shao, Zhenzhen Dou, Chuanfeng An, Zhumei Zhuang,Yonghao Luo, Yi Wang, Jinrong Wu, Ping Ji, Tao Chen*, Huanan Wang*, Entanglement-Driven Adhesion, Self-healing and High Stretchability of Double-Network PEG-Based Hydrogels. ACS Applied Materials & Interfaces 2019, 11, 40, 36458-36468 (IF=8.46)

9. Liyuan Zhang, Kaiwen Chen, Haoyue Zhang, Bo Pang, Chang-Hyung Choi, Angelo S. Mao, Hongbing Liao, Stefanie Utech, David J. Mooney, Huanan Wang*, David A. Weitz*; Microfluidic Templated Multi-compartment Microgels for 3D Encapsulation and Paring of Single Cells; Small, 2018, 14, 1702955.IF=10.94

10. Yi Wang, Zhenxing Cao, Jinrong Wu, Changshu Ma, Cuibo Qiu, Yachao Zhao, Fei Shao, Huanan Wang, Jing Zheng, Guangsu Huang. "Mechanically robust, ultrastretchable and thermal conducting composite hydrogel and its biomedical applications." Chemical Engineering Journal 360 (2019): 231-242.

11. Dize Li, Kaiwen Chen, Lian Duan, Tiwei Fu, Jiao Li, Si Wang, Qin Zou, Li Chen, Yangyingfan Feng, Huanan Wang, Tao Chen*, Strontium Ranelate Incorporated Enzyme-Cross-Linked Gelatin Nanoparticle/Silk Fibroin Aerogel for Osteogenesis in OVX-Induced Osteoporosis. ACS Biomaterials Science & Engineering, 2019, 5 (3), 1440-1451.IF=4.12

12. Mani Diba#, Huanan Wang#, Thomas E. Kodger, Shima Parsa, Sander C. G. Leeuwenburgh. Highly Elastic and Self‐Healing Composite Colloidal Gels. Advanced Materials. 2017, 29, 1604672

13. Angelo S. Mao, Jae-Won Shin, Steffi Utech, Huanan Wang, Oktay Uzun, David A. Weitz, David J. Mooney. Deterministic encapsulation of single cells in thin tunable microgels for niche modeling and therapeutic delivery. Nature Materials. 2017;16 (2) :236-243

14. Hu Y, Mao AS, Desai RM, Wang H, Weitz DA, Mooney DJ. Controlled self-assembly of alginate microgels by rapidly binding molecule pairs. Lab Chip. 2017;17 (14) :2481-2490. (IF=6.12)

15. Xu, Zhongbin; Huang, Xing; Wang, Pengfei*; Ruan, Xiaodong; Wang, Huanan*. Numerical Simulation of a Flow-based Microfluidic Gradient Generator. Microfluidics and Nanofluidics, 2016. 20: 89. (共同通讯作者) (IF=2.537)

16. Chang-Hyung Choi,# Huanan Wang,#,* Hyomin Lee, June Hwan Kim, Liyuan Zhang, Angelo Mao, David J. Mooney, David A. Weitz*. One-step generation of cell-laden microgels using double emulsion drops with a sacrificial ultra-thin oil shell. Lab on a Chip. 2016, 16, 1549–1555. IF=6.12 (共同一作,共同通讯)

17. Mani Diba#, Huanan Wang#, Thomas E. Kodger, Shima Parsa, and Sander C. G. Leeuwenburgh*. Highly Elastic and Self-Healing Composite Colloidal Gels. Advanced Materials. 2017.  DOI: 10.1002/adma.201604672.

 
     18. Huanan Wang, Matilde Bongio, Kambiz Farbod, Arnold WG Nijhuis, Jeroen van den Beucken, Otto C Boerman, Jan van Hest, Yubao Li, John A Jansen, Sander CG Leeuwenburgh, Development of injectable organic/inorganic colloidal composite gels made of self-assembling gelatin nanospheres and calcium phosphate nanocrystals. Acta Biomaterialia, 2014.1,10 (1), 508-519. SCI000329893300050, IF:6.191 (5.684)他引2JCR: Q1(ENGINEERING, BIOMEDICAL)

 

19.Huanan Wang, Q. Zou, O.C. Boerman, Y. Li, J.A. Jansen, S.C.G. Leeuwenburgh, Combined delivery of BMP-2 and bFGF from nanostructured colloidal gelatin gels and its effect on bone regeneration in vivo. Journal of Controlled Release, 2013.3, 166 (2), 172-181. SCI000316464800010,IF: 7.768 (7.261)他引24次,JCR: Q1 (PHARMACOLOGY & PHARMACY)

20. J. van der Stok*, Huana Wang* (*共同第一作者), S. A. Yavari, M. Siebelt, M. Sandker, J.H. Waarsing, H. Jahr, A.A. Zadpoor, S.C.G. Leeuwenburgh, H. Weinans, Bone regeneration in critical-sized defects using growth factor-loaded nanostructured colloidal gelatin gels incorporated into porous titanium scaffolds, Tissue Engineering Part A. 2013. 19 (23-24), 2605-2614. SCI000328333700008, IF: 5.444 (4.254)他引15次,JCR: Q2 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

21. Huanan Wang, O.C. Boerman, Y. Li, J.A. Jansen, S.C.G. Leeuwenburgh, Comparison of micro- vs nano-structured colloidal gelatin gels as injectable delivery vehicles for osteogenic proteins-bone morphogenetic proteins-2 and alkaline phosphatases, Biomaterials, 2012. 33: 8695-8703. SCI000310401000047, IF: 8.911, (8.312)他引20次,JCR: Q1 (MATERIALS SCIENCE, BIOMATERIALS)

22. Huanan Wang, S.C.G. Leeuwenburgh, Y. Li, J.A. Jansen, The use of micro- and nanospheres as functional components for bone tissue regeneration, Tissue Engineering Part B: Reviews, 2012, 18(1): 24-39. SCI000299601500003, IF: 5.444 (4.254)他引34次,JCR: Q2 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

23. Huanan Wang, M.B. Hansen, D.W.P.M. Löwik, J.C.M.v. Hest, Y. Li, J.A. Jansen, S.C.G. Leeuwenburgh, Oppositely charged gelatin nanospheres as building blocks for injectable and biodegradable gels Advanced Materials 2011. 23(12): H119-124.

MaterialsViews Nanowerk重点报道, link:

24. Huanan Wang, Y. Zuo, Q. Zou, L. Cheng, D. Huang, L. Wang, Y. Li, Nano-hydroxyapatite/ polyamide66 composite tissue-engineering scaffolds with anisotropy in morphology and mechanical behaviors, Journal of Polymer Science Part A: Polymer Chemistry, 2009, 47(3):658-669. SCI000262931800014, IF: 3.242, (3.245)他引20次,JCR:Q2 (POLYMER SCIENCE)

25. Huanan Wang, Y. Li, Y. Zuo, J. Li, S. Ma, L. Cheng, Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering, Biomaterials, 2007;28:3338–3348. SCI000247045600008, IF: 8.911 (8.312)他引306, JCR: Q1 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

Biomaterials杂志评为Top 50最高引用率奖

26. Huanan Wang, Y. Li, Y. Zuo, L. Cheng, Y. Wang, H. Li. Nano-hydroxyapatite/polymer composite scaffold for bone tissue engineering, Key Engineering Materials, 2007.330-332:365-368. (SCI000245026800090他引0)

27.王华楠,李玉宝,左奕,程琳,王园园,石浦江. 骨组织工程用n-HA/PA66多孔贯通支架的制备及表征;高分子材料科学与工程,2007; 23(1):230-233. (EI收录,他引次数:5)

28. Xin Zhao, Shen Liu, Lara Yildirimer, Hong Zhao, Ruihua Ding, Huanan Wang, Wenguo Cui,* David Weitz,* Injectable Stem Cell-Laden Photocrosslinkable Microspheres Fabricated Using Microfluidics for Rapid Generation of Osteogenic Tissue Constructs. Advanced Functional Materials. 2016, 26, 17, 2809–2819.

29. Ji W, Huanan Wang, JJJP. van den Beucken, F. Yang, XF. Walboomers, S. Leeuwenburgh, J.A. Jansen. Local delivery of small and large biomolecules in craniomaxillofacial bone, Advanced Drug Delivery Reviews. 2012, 64 (12), 1152-1164. SCI000308626800009, IF: 15.271 (12.707)他引9 次,JCRQ1 (PHARMACOLOGY & PHARMACY)

30. Michelle T Poldervaart, Huanan Wang, Johan van der Stok, Harrie Weinans, Sander CG Leeuwenburgh, F Cumhur Öner, Wouter JA Dhert, Jacqueline Alblas, Sustained release of BMP-2 in bioprinted alginate for osteogenicity in mice and rats, PloS One, 2013, 8 (8), e72610. SCI000323425700181, IF: 4.015 (3.533)他引8次,JCR: Q3 (MULTIDISCIPLINARY SCIENCES)

31. Yi Deng, Huanan Wang, Li Zhang, Yubao Li, Shicheng Wei. In situ synthesis and in vitro biocompatibility of needle-like nano-hydroxyapatite in agar–gelatin co-hydrogel. Materials Letters. 2013; 104:8-12. SCI000320142500003IF: 2.288 (2.269)引:6次,JCR: Q2MATERIALS SCIENCE, MULTIDISCIPLINARY)

32. R.P. Félix Lanao, K. Sariibrahimoglu, Huanan Wang, Joop GC Wolke, John A Jansen, Sander CG Leeuwenburgh, Accelerated Calcium Phosphate Cement Degradation Due to Incorporation of Glucono-Delta-Lactone Microparticles, Tissue Engineering Part A, 2013, 20 (1-2), 378-388. SCI000337280600035, IF: 5.444 (4.254)引用:2次,JCR: Q2 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

32. S.C.G. Leeuwenburgh, J. Jo, Huanan Wang, M. Yamamoto, J.A. Jansen, Y. Tabata, Mineralization, biodegradation, and drug release behavior of gelatin/apatite composite microspheres for bone regeneration, Biomacromolecules, 2010.11(10):2653-2659. SCI000282840200015, IF: 6.034 (5.788)他引19 , JCR: Q2BIOCHEMISTRY & MOLECULAR BIOLOGY)

33. M Zhao, J Li, Y Li, J Wang, Y Zuo, J Jiang, H Wang, Gradient Control of the Adhesive Force between Ti/TiO2 Nanotubular Arrays Fabricated by Anodization, Scientific reports, 2014. 4. doi:10.1038/srep07178, SCI000346184200007, IF:因子: 5.078 (5.078)引用:0次,JCR: Q2 (MULTIDISCIPLINARY SCIENCES)

34. H Jiang, Y Zuo, Q Zou, Huanan Wang, J Du, Y Li, X Yang, Biomimetic Spiral-Cylindrical Scaffold Based on Hybrid Chitosan/Cellulose/Nano-Hydroxyapatite Membrane for Bone Regeneration, 2013, ACS applied materials & interfaces, 2013, 5 (22), 12036-12044. SCI: 000327812300075, IF: 5.908 (5.9)引用:5次,JCR: Q1 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

35. H Jiang, Y Zuo, L Cheng, Huanan Wang, A Gu, Y Li. A homogenous CS/NaCMC/n-HA polyelectrolyte complex membrane prepared by gradual electrostatic assembling. Journal of Materials Science: Materials in Medicine. 2011. 22 (2), 289-297. SCI: 000288458700011, IF: 2.741 (2.379)他引4次,JCR: Q2 (ENGINEERING, BIOMEDICAL)

36. L Cheng, Y Zuo, Q Zou, J Li, Huanan Wang, J Shen, H Jiang, L Wang, Y Li, Effect of vanillin on the miscibility of poly (vinyl alcohol)/gelatin composite hydrogel: Physical and chemical properties, Journal of Applied Polymer Science, 2010, 117 (6), 3687-3693. SCI000279958200076IF: 1.635 (1.64),他引:3次,JCR: Q4(POLYMER SCIENCE)

37. J. Liao, L. Zhang, Y. Zuo, Huanan Wang, J. Li, Q. Zou, Y. Li, Development of nano-hydroxyapatite/polycarbonate composite for bone repair, Journal of Biomaterials Applications, 2009, 24:31-45. SCI000267377900003, IF: 2.752 (2.764),他引19次,JCR: Q2 (MATERIALS SCIENCE, BIOMATERIALS)

38. J. Li, Y. Zuo, X Cheng, W Yang, Huanan Wang, Y. Li, Preparation and characterization of nano-hydroxyapatite/polyamide 66 composite GBR membrane with asymmetric porous structure, Journal of Materials ScienceMaterials in Medicine, 2009, 20:1031-8. SCI000264837700004, IF: 2.741 (2.379),他引:23 次,JCR: Q2 (ENGINEERING, BIOMEDICAL)

39. K. Liu, Y. Li, F. Xu, Y. Zuo, L. Zhang, Huanan Wang, J. Liao, Graphite/poly (vinyl alcohol) hydrogel composite as porous ringy skirt for artificial cornea, Materials Science and Engineering: C, 2009.29(1): 261-266. SCI: 000262136700042, IF: 3.076 (2.736)他引:20次, JCR: Q2 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

40. X. Cheng, Y. Li, Y. Zuo, L. Zhang, J. Li, Huanan Wang, Properties and in vitro biological evaluation of nano-hydroxyapatite/chitosan membranes for bone guided regeneration, Materials Science and Engineering: C, 2009. 29(1), 29-35. SCI: 000262136700006, 000262136700006 IF: 3.076 (2.409),他引:31次,JCR: Q2 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

41. L Cheng, Y Li, Y Zuo, J Li, Huanan Wang, Nano-hydroxyapatite/polyamide 6 scaffold as potential tissue engineered bone substitutes, Materials Research Innovations, 2008.12:192-9. SCI: 000262710500009, IF: 0.491 (0.473),他引:6次,JCR: Q4 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

42. G. Zhou, Y. Li, L. Zhang, H. Li, M. Wang, L. Cheng, Y. Wang, Huanan Wang, P. Shi, The study of tri-phasic interactions in nano-hydroxyapatite/konjac glucomannan/chitosan composite, Journal of Materials Science. 2007, 42(8), 2591-2597. SCI000245431200010, IF: 2.303 (2.305),他引:13次,JCR:Q2 (MATERIALS SCIENCE, MULTIDISCIPLINARY)

43. Xiang, HZ; Li, YB; Mu, YH; Wang, XJ; Hunan Wang, Li, H. Preparation and characterization of n-HA/PA66/CS biocomposite, Key Engineering Materials, 2007, 330-332 (1-2):463-466. (SCI000245026800114他引0)

44. L. Cheng, YB Li, Y Zuo, G Zhou, Huanan Wang, MB Wang, Preparation of Nano-Hydroxyapatite/Polyamide6 Composite Porous Scaffold for Bone Tissue Engineering, Materials science forum. 2007, 544, 793-796. (SCI000246224300198他引0)

45. YY Wang, YB Li, Y Zuo, Huanan Wang, L Cheng, G Zhou. The Influence of Preparation Condition on Nano-Hydroxyapatite Prepared in Different Solvent, Materials Science Forum. 2007. 544, 897. (SCI000246224300224他引0)

46. PJ Shi, YB Li, L Zhang, Y Zuo, M Wu, Huanan Wang, Fabrication of n-HA/CS Porous Scaffold Carrying Ampicillin-Loaded Microspheres, Materials Science Forum, 2007, 544, 941. (SCI000246224300235他引1)

47. YY Wang, YB Li, Y Zuo, HN Wang, L Cheng, G Zhou; Manufacturing Using a More Environmentally Friendly Process as well as Biomaterials-The Influence of Preparation Condition on Nano-Hydroxyapatite Prepared in Different Solvent; Materials Science Forum 544, 897

48. Z Gang, L Yubao, Z Li, L Hong, W Mingbo, C Lin, W Yuanyuan, Wang Huanan; The study of tri-phasic interactions in nano-hydroxyapatite/konjac glucomannan/chitosan composite. Journal of Materials Science 42 (8), 2591-2597

49. Zuo, Y; Li, YB; Zhang, X; Yang, WH; Li, JD; Mo, LR; Huanan Wang, Effect of compatibilizers on the properties of nano-hydroxyapatite reinforced polyamide 66 and high density polyethylene blends, Materials Science Forum, 2006, 510-511 : 978-981. (SCI000237176000245他引0)

50. Q ZOU, L ZHANG, Y ZUO, H WANG, Y LI, X LI; Characterization and cytocompatibility of nano-hydroxyapatite/chitosan bone cement consisting of astragalus polysaccharides; Journal of Functional Materials 9, 028

51. D HUANG, J LI, Y ZUO, Q ZOU, H WANG, Y LI; Fabrication and property of nano-hydroxyapatite/polyamide66 scaffolds modified with chitosan; Journal of Functional Materials 7, 034

 



著作情况

1. Huanan Wang. Nanostructured Colloidal Gelatin Gels for Bone Tissue Regeneration. 2013. pp1-219. Uitgeverij BOXPress, Oisterwijk. Nijmegen, the Netherlands. (著作)

2. Huanan Wang, S.C.G. Leeuwenburgh, Y. Li, J.A. Jansen. Micro- and Nanospheres for Tissue Engineering. Book chapter in handbook of “Micro and Nanotechnologies in Engineering Stem cells and Tissues”, 2013. 202-219. Wiley-IEEE press. (著作章节)

3. Jingrong Wu, Liheng Cai, Huanan Wang*. Advanced Materials for Self-healing Applications. Book chapter in "Design, Fabrication, Properties and Applications of Smart and Advanced Materials", 2014 . p308-341. CRC Press. (通讯作者)(著作章节)

4. M Diba, H Wang, S Leeuwenburgh; Development of self healing gels based on reversible cohesive interaction between self-assembling organic and inorganic nanoparticles; Self Healing Materials: Pioneering Research in the Netherlands, 37.(著作章节)

 



团队成员
带头人
教授
副教授
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联系方式

王华楠 博士 教授

办公地点:大连理工大学生物工程学院525室

E-mail:huananwang@

Tel:+86-411-84708083