课题组主要研究目标：设计、合成和表征用于生物医学领域的新材料；集中在先进智能材料和仿生材料研究开发、表面/界面分子工程、化学/生物分子传感器研究、体外仿生细胞微环境构建等；研究项目涉及材料科学、高分子化学、纳米科学、生物科学与技术、及胶体表面化学等多学科交叉领域。

课题组主要研究方向：（1）设计合成智能响应（如温度响应、光响应）材料，体外构建仿生细胞生长微环境，用于组织再生、药物筛选及疾病模型构建；（2）材料表面修饰及功能化，特别是设计修饰纳米材料，使其集诊断-治疗-追踪监测多功能于一体，用于智能化、个体化医药；（3）开发便携式分子检测与诊断装置，特别是研究开发免标记液晶检测技术。

The overall research goal is to design, synthesize and characterize advanced materials for biomedical and other applications. The research is a multi-displinary program including materials science, polymer chemistry, surface and interface science, biotechnology and nanotechnology.

Specifically, the current research focuses on 1) creating programmable matrix with multifarious properties in order to recapitulate the dynamic nature of native tissue for regenerative medicine and disease modeling; 2) developing stimuli-responsive theranostics with the ability of detecting, diagnosis and treatment of diseases for personalized medicine; and 3) developing point-of-care devices for medical diagnosis, environmental monitoring, and food safety.

►Research Interests

1. K.-Y. Yang, C. -Y. Xue and Saif. A. Khan, Bioassay using Liquid Crystals, US 61/103,020, World Intellectual Property Publication (WO 2010/042070), 2010.

2. K.-Y. Yang, C. -Y. Xue, UV Lithography on Polymer Surfaces for Fabricationg Microstructures and Microfluidic Channels, US 61/321,556, 2010.

1. Li, M.; Cheng, F.; Xue, C.; Wang, H.; Chen, C.; Du, Q.; Ge, D.; Ma, X.; Sun, B. “Surface Modification of Stöber Silica Nanoparticles with Controlled Moiety Densities Determines Their Cytotoxicity”. Langmuir, 35(45), 14688-14695, 2019.

2. Qiqi Du , Dan Ge, Vahid Mirshafiee, Chen Chen, Min Li, Changying Xue, Xuehu Ma, Bingbing Sun, Assessment of Neurotoxicity Induced by Different-Sized Stöber Silica: Induction of Pyroptosis in Microglia, Nanoscale, 11, 12965-12972, 2019.

3. C.-Y. Xue, D.Y. Wong, Andrea M. Kasko, Complex Dynamic Substrate Control: Dual-tone Hydrogel Photoresists Allow Double-dissociation of Topography and Modulus, Advanced Materials, 26(10), 1577-1583, 2014.

4. S. Choi, B-C Choi, C.-Y. Xue, Deborah E. Leckband, Protein Adsorption Mechanisms Determine the Efficiency of Thermally Controlled Cell Adhesion on Poly(N-isopropyl acrylamide) Brushes, Biomacromolecules, 14(1), 92-100, 2013.

5. C.-Y. Xue, C. Choi, S. Choi, Paul V. Braun and Deborah E. Leckband, Protein Adsorption Modes Determine Reversible Cell Attachment on Poly(N-isopropylacrylamide) Brushes, Advanced Functional Materials, 22(11), 2394-2401, 2012.

6. Nicolas Brouette, C.-Y. Xue, Michael Haertlein, Martine Moulin, Giovanna Fragneto, Deborah E. Leckband, Avraham Halperin, and Michele Sferrazza, Protein Adsorption Properties of OEG Monolayers and Dense PNIPAM Brushes Probed by Neutron Reflectivity, The European Physical Journal Special Topics, 213, 343-353, 2012.

7. C.-Y. Xue, N. Yonet-Tanyeri, Nicolas Brouette, Michele Sferrazza, Paul V. Braun, and Deborah E. Leckband, Protein Adsorption on Poly(N-isopropylacrylamide) Brushes: Dependence on Grafting Density and Chain Collapse, Langmuir, 27(14), 8810-8818, 2011.

8. C.-Y. Xue, W. Zhang, Wan Hui Stella Choo, and K.-L Yang, Simplest Method for Creating Micropatterned Nanostructures on PDMS with UV Light, Langmuir, 27(22), 13410-13414, 2011.

9. W. Zhang, W.T. Ang, C.-Y. Xue, and K.-L Yang, Minimizing Nonspecific Protein Adsorption in Liquid Crystal Immunoassays by Using Surfactants, ACS Applied Materials & Interfaces, 3(9), 3496-3500, 2011.

10. C.-Y. Xue, S.Y. Chin, Saif A. Khan, K.-L Yang, UV-Defined Flat PDMS Stamps Suitable for Microcontact Printing, Langmuir, 26 (5), 3739-3743, 2010.

11. W. Zhang, C.-Y. Xue, K.-L Yang, A Method of Printing Uniform Protein Lines by Using Flat PDMS Stamps, Journal of Colloid and Interface Science, 353 (1), 143-148, 2011.

12. C.-Y. Xue, Saif A. Khan, K.-L Yang, One-step UV Lithography for Activation of Inert Hydrocarbon Monolayers and Preparation of Protein Micropatterns, Journal of Colloid and Interface Science, 344 (1), 48-53, 2010.

13. C.-Y. Xue, Saif A. Khan, K.-L Yang, Exploring Optical Properties of Liquid Crystals for Developing Label-Free and High Throughput Microfluidic Immunoassays, Advanced Materials, 21 (2), 198-202, 2009. Highlighted by NPG Asia Materials, doi:10.1038/asiamat.2009.122, (2009).

14. Deny Hartono, C.-Y. Xue, Lin-Yue Lanry Yung, K.-L Yang, Decorating Liquid Crystal Surfaces with Proteins for Real-Time Detection of Specific Protein–Protein Binding, Advanced Functional Materials, 19 (22), 3574-3579, 2009.

15. C.-Y. Xue, Deny Hartono, K.-L Yang, Controlling and Manipulating Supported Phospholipid Monolayers as Soft Resist Layers for Fabricating Chemically Micropatterned Surfaces, Langmuir, 24 (19), 11282-11286, 2008.

16. C.-Y. Xue, K.-L Yang, Dark-to-Bright Optical Responses of Liquid Crystals Triggered by Proteins Absorbed on Solid Surfaces, Langmuir, 24 (2), 563-567, 2008.

17. C.-Y. Xue, K.-L Yang, Chemical Modifications of Inert Organic Monolayers with Oxygen Plasma for Biosensor Applications, Langmuir, 23 (10), 5831-5835, 2007.

18. Y.T. Chen, T.Q. Liu, C.-Y. Xue, Y. Liu, Effects of Nanotopography of Bioactive Surface on Pseudomonas Fluorescence Cell Adhesion, Journal of Biomedical Engineering, 22 (3), 443-447, 2005.

19. C.-Y. Xue, T.Q. Liu, D. Ge, X.Y. Sun, X.H. Ma, Optimal Protocols to Expand Neural Stem Cells in Rotating Wall Vessel Bioreactor, Journal of Biomedical Engineering, 22 (3 Suppl.), 85-86, 2005.

changyingxue@