生物催化转化：围绕精细化学品生物制造的科学问题及关键技术，开展酶结构与功能、代谢工程及过程工程研究。包括（1）蛋白质及酶工程；（2）酶制剂开发及应用；（3）代谢工程及代谢控制发酵。重点开展蛋白酶、脂肪酶、氧化还原酶的酶工程及应用，丁二酮、苹果酸等精细化学品的微生物发酵研究。
天然药物药物化学与药理学：围绕药物化学与药理学及新药发现等科学问题及关键技术，开展药物药理、药效、协同作用以及应用的研究。包括（1）神经退行性疾病药物研究；（2）抗肿瘤药物协同作用；（3）继发性骨质疏松保健及治疗（4）酒精依赖及酒精中毒的预防及治疗。
近几年获国家发明专利4项，发表SCI收录50余篇。
Jianli Guo, Qin Tang, Qingling Wang, Wenhui Sun, Zhongji Pu, Jingyun Wang, Yongming Bao. Pifithrin-αenhancing anticancer effect of topotecan on p53- expressing cancer cells.European Journal of Pharmaceutical Sciences 2019, 128: 61–72.
Bo Jiang, Shangli Zheng, Lijia An. Changes in striatal dopamine transporter and tyrosine hydroxylase expression associated with fatigue and their reversal by blueberry juice Journal of Berry Research 2019, 99:1-12.
Zhongji Pu, Mengdi Zhao,Yue Zhang,Wenhui Sun, Yongming Bao. Dynamic Description of the Catalytic Cycle of Malate Enzyme: Stereoselective Recognition of Substrate, Chemical Reaction, and Ligand Release. J. Phys. Chem. B 2018, 122, 12241−12250.
Qingling Wang, Fangling Ji, Jianli Guo, Yuepeng Wang, Yanyan Li, Jingyun Wang, Lijia An, Yongming Bao. LotS/LotR/Clp, a novel signal pathway responding to temperature, modulating protease expression via c-di-GMP mediated manner in Stenotrophomonas maltophilia FF11.Microbiological Research 2018, 214: 60–73.
Meiling Gao, Siyu Yao, Yang Liu, Haining Yu, Pinsan Xu, Wenhui Sun, Zhongji Pu, Hongman Hou, Yongming Bao. Transcriptome Analysis of Tomato Leaf Spot Pathogen Fusarium proliferatum: De novo Assembly, Expression Profiling, and Identification of Candidate Effectors.Int. J. Mol. Sci. 2018, 19(31),doi:10.33-39
Yue Zhang, Fangling Ji, Jingyun Wang, Zhongji Pu, Bo Jiang, Yongming Bao. Purification and characterization of a novel organic solvent tolerant and cold adapted lipase fromPsychrobactersp. ZY124. Extremophiles 2018, 22: 287–300.
Wenbo Hao, Fangling Ji, Jingyun Wang, Yuepeng Wang, Yue Zhang, Yongming Bao. Metabolic engineering of Bacillus sp. for diacetyl production.Process Biochemistry2017, 58: 69–77.
Qin Tang, Fangling Ji, Jingyun Wang, Lianying Guo, Yachen Li, Yongming Bao.Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin. European Journal of Pharmaceutical Sciences 2017, 109: 223-232.
Zhongji Pu, Fangling Ji, Jingyun Wang, Yue Zhang, Wenhui Sun,Yongming Bao. Rational design of Meso-2, 3-butanediol dehydrogenase by molecular dynamics simulation and experimental evaluations. FEBS Letter 2017,591: 3402-3413.
Bo. Jiang , R.F. Shen, J. Bia, X.S. Tianb, T Hinchliffeb Y. Xia. Catalpol: A Potential Therapeutic for Neurodegenerative Diseases Current Medicinal Chemistry,2015, 22(10):1278-1291
代表性成果
国家发明专利
Jianli Guo, Qin Tang, Qingling Wang, Wenhui Sun, Zhongji Pu, Jingyun Wang, Yongming Bao. Pifithrin-αenhancing anticancer effect of topotecan on p53- expressing cancer cells.European Journal of Pharmaceutical Sciences 2019, 128: 61–72.
Bo Jiang, Shangli Zheng, Lijia An. Changes in striatal dopamine transporter and tyrosine hydroxylase expression associated with fatigue and their reversal by blueberry juice Journal of Berry Research 2019, 99:1-12.
Zhongji Pu, Mengdi Zhao,Yue Zhang,Wenhui Sun, Yongming Bao. Dynamic Description of the Catalytic Cycle of Malate Enzyme: Stereoselective Recognition of Substrate, Chemical Reaction, and Ligand Release. J. Phys. Chem. B 2018, 122, 12241−12250.
Qingling Wang, Fangling Ji, Jianli Guo, Yuepeng Wang, Yanyan Li, Jingyun Wang, Lijia An, Yongming Bao. LotS/LotR/Clp, a novel signal pathway responding to temperature, modulating protease expression via c-di-GMP mediated manner in Stenotrophomonas maltophilia FF11.Microbiological Research 2018, 214: 60–73.
Meiling Gao, Siyu Yao, Yang Liu, Haining Yu, Pinsan Xu, Wenhui Sun, Zhongji Pu, Hongman Hou, Yongming Bao. Transcriptome Analysis of Tomato Leaf Spot Pathogen Fusarium proliferatum: De novo Assembly, Expression Profiling, and Identification of Candidate Effectors.Int. J. Mol. Sci. 2018, 19(31),doi:10.33-39
Yue Zhang, Fangling Ji, Jingyun Wang, Zhongji Pu, Bo Jiang, Yongming Bao. Purification and characterization of a novel organic solvent tolerant and cold adapted lipase fromPsychrobactersp. ZY124. Extremophiles 2018, 22: 287–300.
Wenbo Hao, Fangling Ji, Jingyun Wang, Yuepeng Wang, Yue Zhang, Yongming Bao. Metabolic engineering of Bacillus sp. for diacetyl production.Process Biochemistry2017, 58: 69–77.
Qin Tang, Fangling Ji, Jingyun Wang, Lianying Guo, Yachen Li, Yongming Bao.Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin. European Journal of Pharmaceutical Sciences 2017, 109: 223-232.
Zhongji Pu, Fangling Ji, Jingyun Wang, Yue Zhang, Wenhui Sun,Yongming Bao. Rational design of Meso-2, 3-butanediol dehydrogenase by molecular dynamics simulation and experimental evaluations. FEBS Letter 2017,591: 3402-3413.
Bo. Jiang , R.F. Shen, J. Bia, X.S. Tianb, T Hinchliffeb Y. Xia. Catalpol: A Potential Therapeutic for Neurodegenerative Diseases Current Medicinal Chemistry,2015, 22(10):1278-1291
