纳米医药工程研究室-大连理工大学生物工程学院（新）

团队简介

纳米医药技术以介观量级尺寸对材料的分子（组装）结构进行分析和操控，是纳米技术与生物学的结合，在生物医学领域应用，具有对单个或多个生物活性分子进行时空精准探测、修饰、操控、运输等潜力，从而为分子生物研究提供强大的解析工具、对重大疾病实现高精度监测和精准的时空调控，尤其微纳米医用材料在药物定点定位递送&控释、基因编辑、生物微环境监测等方面具有重大的应用前景。

随着中国逐步进入老龄化社会，根据《国家创新驱动发展战略纲要》，发展安全、有效、便捷的健康技术，应对人口老龄化的挑战，是生物医学研究的重点方向。微纳米生物材料是国际生物技术领域的前沿和热点，在医药卫生领域有着广泛的应用和明确的产业化前景，特别是纳米药物载体、纳米生物传感器和成像技术以及微型智能化医疗器械等，在疾病的诊断、治疗和卫生保健方面发挥重要作用。美国、日本、德国等国家均已将纳米生物技术作为21世纪的科研优先项目予以重点发展。目前我国生物医疗材料产业以传统材料工艺为主，在高性能的微纳米生物材料发展上落后于上述发达国家，医疗产业的微纳米生物材料引进为主，虽然近年来在材料基础研发上取得了阶段性进步，然而微纳米生物材料的产业化水平仍较为薄弱，是我国生物医药产业达到国际先进水平的主要瓶颈。

纳米医药研究室研究室，隶属于大连理工大学生物医学工程学院，以纳米医用材料研究为核心，目前的研究方向包括1）基因药物递送系统的开发和应用：通过设计合成安全高效的基因递送功能分子，构建了包载DNA的纳米输运载体，基于对DNA凝缩理论的系统和深入研究，实现了对包载凝缩DNA纳米运载体的尺寸、形状和形状的精准控制，在病灶部位实现了持续高效的表达药用蛋白。2）克服血脑屏障的高渗透药物递送系统：针对脑退化疾病（阿尔海默病、帕金森病等）开发高效通透血脑屏障的药物递送系统，实现靶向输送药物到神经元细胞或胶质细胞。3）肿瘤高靶向性、高渗透性纳米药物递送系统的研究：构建多功能、环境响应型、靶向性、智能化的聚合物纳米药物递送系统，通过对聚合物高分子的分子结构及其组装的纳米精准控制，实现对各类恶性肿瘤实现高效的治疗效果。4）具有响应性，功能性的生物水凝胶：针对人类重大慢性病（如眼科疾病：白内障，葡萄糖膜炎等疾病）以及人类重大疾病（原发或复发性恶性癌症等）开发的的高度可控的模块化介入型的纳米药物缓释体技术。目前微纳米生物材料研究团队在肿瘤等重大疾病的早期精准诊断和靶向治疗领域取得了突出的进展，近5年在国际著名学术期刊Nature Nanotechnology、Nature Communications、ACS Central Science、ACS Nano、Chemistry of Materials、Biomaterials、Small、Journal of Controlled Release、Molecular Therapy等发表论文60余篇、10余项发明专利以及针对高阶脑胶质瘤和眼部慢性病2项临床转化技术。

未来纳米医药研究室将注重研究深度和产业转化的提升，基础研究的重点包括：精密表微观结构的纳米功能/智能材料的可控制备、纳米生物材料的分子设计及其结构控制及其与生物分子及细胞之间的相互作用、纳米控释给药系统、纳米分子影像探针构建以及纳米材料器件与分子组学等纳米生物医学方向；产业化重点以威胁人类健康的重大疾病（包括：癌症、中枢神经退行性疾病）为目标，推动发展靶向给药纳米技术、肿瘤微环境纳米药物、精准医学纳米技术、肿瘤免疫治疗纳米药物等平台技术，为国家全面迈入小康社会提供有效的医疗保障。

代表性成果

1. S. Chen^#,Q. Chen^#, Q. Li, J. An, P. Sun, J. Ma, H. Gao^*, Biodegradable synthetic antimicrobial with aggregation induced emissive luminogens for temporal antibacterial activity and facile bacteria detection.Chemistry of Materials, 30, 1782, 2018. (影响因子：10.159)

2. W. Wang^#, S. Wu^#, J Wang, Z. Li, H. Cui, S. Lin, J. Zhu, Q. Chen^*, Superoxide dismutase transcellular shuttle constructed from dendritic MOF and charge reversible protein derivatives.Chemical Science, 10, 4476, 2019.(影响因子：9.556)

3. Q. Chen, K. Osada^*, T. Ishii, M. Oba, S. Uchida, T. A. Tockary, T. Endo, Z. Ge, H. Kinoh, M. R. Kano, K. Itaka, K. Kataoka^*, Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.Biomaterials, 33, 18, 4722, 2012.（影响因子：10.273）

4. Q. Chen, K. Osada^*, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Kim, K. Toh, K. M. Takeda, Y. Li, T. Ishii, M. Oba, Y. Matsumoto, K. Itaka, K. Kataoka^*, Polyplex micelles installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting.Biomaterials, 113, 253, 2016.（影响因子：10.273）

5. Z. Ge^#, Q. Chen^#, K. Osada^*, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka^*, Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors.Biomaterials, 35, 10, 3416, 2014.（影响因子：10.273）

6. Q. Chen^#^,^*, R. Qi^#, X. Chen, H. Xiao, W. Dong^*, Polymeric nanostructure compiled with multifunctional components to exert tumor-targeted delivery of anti-angiogenic gene for tumor growth suppression.ACS Applied Materials & Interfaces, 8, 24404, 2016.（影响因子：8.456）

7. Q. Chen^#,^*, R. Qi^#, X. Chen, X. Yang, S. Wu, H. Xiao, W. Dong^*, A targeted and stable polymeric nanoformulation enhances systemic delivery of mRNA to tumors.Molecular Therapy, 25(1), 92, 2017.（影响因子：8.402）

8. J. Li^#, Q. Chen^#, Z. Zha, K. Toh, A. Dirisala, Y. Matsumoto, K. Osada, K. Kataoka^*, Z. Ge^*, Ternary polyplex micelle with PEG shells and intermediate barrier to complexed DNA cores for efficient gene delivery.Journal of Controlled Release, 209, 77, 2015.（影响因子：7.901）

9. X. Han^#, Q. Chen^#, H. Lu, J. Ma, H. Gao^*, Probe intracellular trafficking of polymeric DNA delivery vehicle by functionalization with aggregation-induced emissive tetraphenylethene derivative.ACS Applied Materials & Interfaces, 7, 28494, 2015.（影响因子：8.456）

10. X. Han^#, Q. Chen^#, W. Lu, G. Wu, J. Ma, H. Gao^*, Incorporation of aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested nucleus translocation of DNA as uncomplexed form.Chemical Communications, 52, 3907, 2016.（影响因子：6.164）

11. T. Wang^#, Q. Chen^#, W. Li, G. Wu, J. Ma, H. Gao^*, Shedding PEG palisade by temporal photo-stimulation and intracellular reducing milieu for facilitated intracellular trafficking and DNA releasing.Bioconjugate Chemistry, 27, 1949, 2016.（影响因子：4.349）

12. D. Liu, X. Han, H. Lu, D. Ma, Q. Chen^*, H. Gao^*, Aggregation-induced-emissive molecule incorporated into polymeric nanoparticulate as FRET donor for observing doxorubicin delivery.ACS Applied Materials & Interfaces, 7, 23760, 2015.（影响因子：8.456）

13. Y. Li, J. Li, B. Chen, Q. Chen^*, G. Zhang, Z. Ge^*, S. Liu, Polyplex micelles with thermo-responsive heterogeneous coronas for prolonged blood retention and promoted gene transfection.Biomacromolecules, 15, 8, 2914, 2014.（影响因子：5.738）

14. J. Li, Y. Han, Q. Chen^*, H. Shi, S. Rehman, M. Siddiq, Y. Liu, Z. Ge^*, S. Liu, Dual endogenous stimuli-responsive polyplex micelles as smart two-step delivery nanocarriers for deep tumor tissue penetration and combating drug resistance of cisplatin.Journal of Materials Chemistry B, 2, 13, 1813, 2014.（影响因子：5.047）

15. D. Liu^#, Q. Chen^#, Y. Long, J. Ma, H. Gao^*, A thermo-responsive polyurethane organogel for norfloxacin delivery.Polymer Chemistry, 9, 228, 2018.（影响因子：4.927）

16. X. Yang, Q. Chen^*, J. Yang, S. Wu, J. Liu, Z. Li, D. Liu, X. Chen, Y. Qiu*, Tumor-targeted accumulation of ligand-installed polymeric micelles depends on PEGylation crowdedness.ACS Applied Materials & Interfaces, 9(50), 44045-44052, 2017.（影响因子：8.456）

17. Z. Jiang, Q. Chen^*, X. Yang, X. Chen, Z. Li, D. Liu, W. Li, Y. Lei, H. Gao^*, Polyplex micelle with pH-responsive PEG detachment and functional tetraphenylene incorporation to promote systemic gene expression.Bioconjugate Chemistry, 28 (11), 2849-2858, 2017.（影响因子：4.349）

18. J. Yang, R. Liang, Y. Chen^*, C. Zhang, R. Zhang, X. Wang, R. Kang, Q. Chen^*, Using a self-assemblable nucleating agent to tailor crystallization behavior, crystal morphology, polymorphic crystalline structure, and biodegradability of poly(1,4-butylene adipate).Industrial & Engineering Chemistry Research, 56(28), 7910-7919, 2017.（影响因子：3.141）

19. J. Yang^*, X. Wang, R.Liang, R. Kong, Y. Sun, J. Tang, L. Li, L. Xue, Q. Chen^*, Polymorphism, thermal stability and biodegradation of poly(1,4-butylene adipate) manipulated by a benzene-1,3,5-tricarboxamide-based nucleating agent.Journal of Materials Science, 53, 10569-10581, 2018. (影响因子: 2.993)

20. Q. Chen, K. Osada^*, P. Matthew, S. Uchida, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Oniyanagi, K. Itaka, K. Kataoka^*, A tadpole-shaped genecarrier with distinct phase segregation in ternary polymeric micelle.Soft Matter, 11, 14, 2718, 2015.（影响因子：3.709）

21. X. Chen^*, H. Gu, J. Yang, S. Wu, J. Liu, X. Yang, Q. Chen^*, Controlled PEGylation crowdedness for polymeric micelles to pursue ligand-specified privileges as nucleic acid delivery vehicles.ACS Applied Materials & Interfaces,9, 8455-8459, 2017.（影响因子：8.456）

22. Y. Huang^#, Q. Chen^#, H. Lu, J. An, H. Zhu, X. Yan, W. Li, H. Gao^*, Near-infrared AIEgen-functionalized and diselenide-linked oligo-ethylenimine with self-sufficing ROS to exert spatiotemporal responsibility for promoted gene delivery.Journal of Materials Chemistry B,6, 6660-6666, 2018.（影响因子：5.047）

23. J. Xia, J. Wang, X. Wang, M. Qian, L. Zhang, Q. Chen^*, Ultrasound-responsive nanoparticulate for selective amplification of chemotherapeutic potency for ablation of solid tumors.Bioconjugate Chemistry, 29(10), 3467-3475, 2018.（影响因子：4.349）

24. H. Zhu, J. An, C. Pang, S. Chen, W. Li, J. Liu, Q. Chen^*, H. Gao^*, A multifunctional polymeric gene delivery system for circumvent biological barriers.Journal of Materials Chemistry B, 7, 384-392, 2019.（影响因子：5.047）

25. S. Chen^#, Q. Chen^#, S. Dong, J. Ma, Y. Yang, L. Chen^*, H. Gao^*, Polymerbrush decorated MOF nanoparticles loaded with AIEgens, anticancer drug, and supramolecular glue for regulating and in situ observing DOX release.Macromolecular Bioscience, 18(12), 1800317, 2018.（影响因子：3.392）

26. P. Sun, Z. Li, J. Wang, H. Gao, X. Yang, S. Wu, D. Liu, Q. Chen^*, Transcellular delivery of messenger RNA payloads by cationic supramolecular MOF platform.Chemical Communications, 54, 11304-11307, 2018.（影响因子：6.164）

27. J. Wang, Y. Xia, H. Liu, J. Xia, M. Qian, L. Zhang, L. Chen, Q. Chen^*, Poly(lactobionamidoethyl methacrylate)-based copolymer with ultrasound-labile motif in manufacture of drug delivery nanoparticulates for augmented efficacy to hepatocellular carcinoma.Journal of Colloid and Interface Science, 551, 1-9, 2019. (影响因子：6.361)

28. H. Fu, Y. Huang, H. Lu, J. An, D. Liu, Y. Zhang, Q. Chen^*, H. Gao^*, A theranostic saponin nano-assembly based on FRET of an aggregation induced emission photosensitizer and photon up-conversion nanoparticles.Journal of Materials Chemistry B, 7, 5286-5290,2019.（影响因子：5.047）

29. L. Zhang, M. Qian, J. Wang^*, J. Xia, H. Cui, Q. Chen^*, Nitrophenyl-engaged photocleavage of an amphiphilic copolymer for spatiotemporally controlled drug release.Journal of Materials Science, 54(20), 13298-13313, 2019.(影响因子: 2.993)

30. J. Xia, J. Li, Q. Yao, M. Qian, H. Cui, L. Zhang, L. Guo, Y. Li, Q. Chen^*, J. Wang^*, X. Peng, Mitochondria specific oxidative injury by near-infrared energy transfer nanoclusters for amplified photodynamic potency.Journal of Colloid and Interface Science, 557, 45-54, 2019.(影响因子：6.361)

31. T. Hao^#, Q. Chen^#, Y. Qi, P. Sun, D. Chen, W. Jiang, K. Liu, H. Sun, L. Li, J. Ding^*, Z. Li^*, Biomineralized Gd₂O₃@HSA nanoparticles as a versatile platform for dual-modal imaging and chemo-phototherapy-synergized tumor ablation.Advanced Healthcare Materials,8, 1901005-1901015,2019.(影响因子：6.27)

32. H. Cui, J. Xia, L. Zhang, M. Qian, H. Wang, J. Wang^*and Q. Chen^*, Integument of cytoplasmic membrane onto cationic DNA condensates for selective gene expression at homologous cells.ACS Applied Bio Materials, 2, 4537-4544,2019.

33. Q. Bai, J. Liu, J. Tang, Z. Li, X. Zheng, Q. Chen^*,Redox-responsive polymeric RNAi based on multivalent conjugation of siRNA for improved intracellular delivery.Bioconjugate Chemistry, 30, 11, 2777-2781, 2019.（影响因子：4.349）

34. X. Zheng, X, Yang, J. Liu,Q. Chen^*,Targeted transportation of anti-VEGF RNAi to glioma by dual-responsive siRNA polymeric constructs for systemic tumor suppression.Small, 2020.

35. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen,M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka^*, Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size.Nature Nanotechnology, 6, 12, 815, 2011.（影响因子：33.407）

36. S. Uchida, K. Itaka^*, Q. Chen, K. Osada, T. Ishii, MA. Shibata, M. Harada-Shiba, K. Kataoka^*, PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses.Molecular Therapy, 20, 6, 1196, 2012.（影响因子：8.402）

37. F. Pittella, K. Miyata^*, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka^*, Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles.Journal of Controlled Release, 161, 3, 868, 2012.（影响因子：7.901）

38. T. A. Tockary, K. Osada^*, Q. Chen, K. Machitani, A. Dirisala, S. Uchida, T. Nomoto, K. Toh, Y. Matsumoto, K. Itaka, K. Nitta, K. Nakayama, K. Kataoka^*, Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers.Macromolecules, 46, 16, 6585, 2013.（影响因子：5.997）

39. A. Dirisala, K. Osada^*, Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka*, Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors.Biomaterials, 35, 20, 5359, 2014.（影响因子：10.273）

40. Y. Li, K. Osada, Q. Chen, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Uchida, K. Nagata, K. Itaka, K. Kataoka^*, Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression.Biomacromolecules, 16, 2664, 2015.（影响因子：5.667）

41. Y. Chen, S. Wang, Q. Chen, Z. Xi, C. Wang, X. Chen, X. Feng, R. Liang, J. Yang^*, Modulated crystallization behavior, polymorphic crystalline structure and enzymatic degradation of poly(butylene adipate): effects of layered metal phosphonate.European Polymer Journal, 72, 222, 2015.（影响因子：3.741）

42. W. Gu, Q. Li, H. Lu, L Fang, Q. Chen, Y. Yang, H. Gao^*, Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery.Chemical Communications, 51, 4715, 2015.（影响因子：6.164）

43. T. A. Tockary, K. Osada, Y. Motoda, S. Hiki, Q. Chen, K. M. Takeda, A. Dirisala, S. Osawa, K. Kataoka^*, Rod-to-globule transition of pDNA/PEG-poly(L-lysine) polyplex micelle induced by a collapsed balance between DNA rigidity and PEG crowdedness.Small, 12, 1193, 2016.（影响因子：10.856）

44. Y. Li, W. Ke, L. Wang, K. Zhao, W. Yin, P. Zhang, Q. Chen, Z. Ge^*, Self-sufficing H₂O₂-responsive nanocarriers through tumor-specific production for synergistic oxidation-chemotherapy.Journal of Controlled Release, 225, 64, 2016.（影响因子：7.901）

45. D. Shao, J. Li, X. Zheng, Y. Pan, Z. Wang, M. Zhang, Q. Chen, W-F. Dong, L. Chen^*, Janus “nano-bullets” for magnetic targeting liver cancer chemotherapy.Biomaterials, 100, 118, 2016.（影响因子：10.273）

46. Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao^*, Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition.Journal of Materials Chemistry B, 4, 6350, 2016.（影响因子：5.047）

47. X. Yang, W. Li, Q. Chen, M. Li, R. Qi^*, Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery effective malignant neuroblastoma treatment.Nanomedicine: Nanotechnology, Biology and Medicine, 13, 287, 2016.（影响因子：5.57）

48. K. M. Takeda, K. Osada, T. A. Tockary, A. Dirisala, Q. Chen, K. Kataoka^*, Poly(ethylene glycol) crowding as critical factor to determine pDNA packaging scheme into polyplex micelle for enhanced gene expression.Biomacromolecules, 18, 36, 2017.（影响因子：5.667）

49. S. Dong, Q. Chen, W. Li, Z. Jiang, J. Ma, H. Gao*, Dendritic catiomer with MOF motif for construction of safe and efficient gene delivery systems.Journal of Materials Chemistry B, 5, 8322, 2017.（影响因子：5.047）

50. R. Qi, Y. Wang, P. Bruno, H. Xiao, Y. Yu, T. Li, S. Lauffer, W. Wei, Q. Chen, X. Kang, H. Song, X. Yang, X. Huang, A. Detappe, U. Matulonis, D. Pépin, M. Hemann, M. Birrer, P. Ghoroghchian^*. Nanoparticle-conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer.Nature Communications, 8(1), 2166, 2017. (影响因子：11.878)

51. H. Gao, H. Takemoto, Q. Chen, M. Naito, K. Miyata, K. Kataoka^*, Regulated protonation behavior of polyaspartamide derivatives bearing repeated aminoethylene side chain for facilitated intracellular siRNA delivery with minimized cytotoxicity.Chemical Communications, 51, 15, 3158, 2015.（影响因子：6.164）

52. X. Yang, Y. Yu, X. Huang, Q. Chen, H. Wu, R. Wang, R. Qi, R. Miao,Y. Qiu^*, Delivery of platinum (II) drugs with bulky ligands in trans-geometry for overcoming cisplatin drug resistance.Materials Science & Engineering C, 96, 96-104, 2019. (影响因子：5.080)

53. P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H. Gao^*, Dual functionalized amino poly (glycerol methacrylate) with guanidine and schiff-base linked imidazole for enhanced gene transfection and minimized cytotoxicity.Journal of Materials Chemistry B, 3, 6911, 2015.（影响因子：5.047）

54. S. Uchida, K. Itaka^*, Q. Chen, K. Osada, K. Miyata, T. Ishii, M. Harada-Shiba, K. Kataoka^*, Combination of chondroitin sulfate and polyplex micelles from poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolongedin vivogene transfection with reduced toxicity.Journal of Controlled Release, 155, 2, 296, 2011.（影响因子：7.786）

55. Z. Lu, S. Zhang, J. Sheng, P. Gao, Q. Chen, Z. Peng, S. Wu^*, J. Ye^*, Rapid crystallization of amorphous silicon films utilizing Ar-H₂mesoplasma, annealing.Journal of Crystal Growth, 486, 142, 2018.（影响因子：1.742)

56. Z. Lu, Z. Zhang, X. Chen, Q. Chen, F. Res, M. Wang, S. Wu, Z. Peng, D. Wang, J. Ye^*, Improving Li anode performance by a porous 3D carbon paper host with plasma assisted sponge carbon coating.Energy Storage Materials, 11, 47-56, 2018.（影响因子：12.38）

57. H. V.-T. Nguyen, Q. Chen, Paletta, J. T. Paletta, P. Harvey, Y. Jiang, H. Zhang, M. D. Boska, M. F. Ottaviani, A. Jasanoff, A. Rajca, J. A. Johnson^*, Nitroxide-based macromolecular contrast agents with unprecedented transverse relaxivity and stability for magnetic resonance imaging of tumors.ACS Central Science, 3, 800-811, 2017.（影响因子: 12.837）

58. K. Itaka, S. Uchida^*, Q. Chen, T. Ishii, K. Osada, K. Kataoka^*, Biocompatible polyplex nanomicelle for safe and effective gene introduction minimizing inflammatory responses.Huamn Gene Therapy, 10, 22, 88, 2011.（影响因子：4.241）

59. H. Zhang, Z. Lu, S. Wu, X. Chen, Q. Chen, P. Gao, Y Yu, Z. Peng, J. Ye^*, Efficient and controllable growth of vertically oriented graphene nanosheets by mesoplasma chemical vapor deposition.Carbon, 147, 341-347, 2019.（影响因子: 7.466）

60. L. Hua, Q. Chen, J. Ying, C. Zhang, J. Yang^*, Fabrication and physical properties of poly(epsilon-caprolactone)/modified graphene nanocomposite.Macromolecular Materials and Engineering, 302(3), 1600328, 2016.（影响因子：2.690）

61. F. Wang, L. Wen, J. Liu, W. Peng, Q. Chen, H. Chen, B. Song, Y. Guo, P. Mi^*, Albumin nanocomposites with MnO₂/Gd₂O₃motifs for precise MR imaging of acute myocardial infarction in rabbit models.Biomaterials, 230, 119614, 2020.（影响因子：10.273）

62. Z. Li, Q. Chen, Y. Qi, Z. Liu, T. Hao, X. Sun, M. Qiao, X. Ma, T. Xu, X. Zhao, C. Yang, D. Chen^*, Rational design of multifunctional polymeric nanoparticles based on poly(L-histidine) and d-α-vitamin E Succinate for reversing tumor multidrug resistance.Biomacromolecules, 19, 2595-2609, 2018.（影响因子：5.667）

63.B. Liu, H. Zhang,Q. Chen,P. Mi^*,Ligand-installed anti-VEGF genomic nanocarriers for effective suppression of primary tumors and metastasis.Journal of Controlled Release, 320, 314-327, 2020.（影响因子：7.786）

64. T. A. Tockary, W. Foo, A. Dirisala,Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka^*,Single-stranded DNA-packaged polyplex micelle asAVV-inspired compacted gene vector to systemically target stroma-rich pancreatic cancer.ACS Nano, 13,12732-12742, 2019.（影响因子：13.709）

65. X. Yan, Q. Chen, J. An. D. Liu, Y. Huang, R. Yang, W. Li, L. Chen, H. Gao^*, Hyaluronic acid/PEGlated amphiphilic nanoparticulates for pursuit of selective intracellular doxorubicin release.Journal of Materials Chemistry B, 7, 95-102, 2019.（影响因子：5.047）

专利情况

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