课题组的研究工作主要聚焦于利用海洋资源高效生产生物质，满足人类社会对健康食品、环保饲料、生物燃料、绿色化学品等重大需求，实现二氧化碳负排放和水体环境净化，解决全球人口膨胀和陆地资源紧张的尖锐矛盾，保障人类社会可持续发展。

Our research focus on efficient production of marine microalgae biomass with sustainable utilization of ocean resources, to meet human society’s increasing demand for healthy food, sustainable animal feed, renewable biofuels, and green chemicals, as well as negative carbon emission and water environment remediation. This addresses the serious problem of land-based resources’ exhaustion and human population expansion, to reach to goal of global sustainable development.

主要研究方向：

• 海上微藻高效农业

• 海洋环境修复和水体生态净化

• 水生动物疫苗微藻合成生物学生产和给药平台

• 先进光生物反应器微藻培养系统开发

• 海洋微生物高密度发酵生产健康食品

• 有机废物和废水的资源化利用

Our on-going researches include:

• High efficient microalgal biomass farming on ocean

• Marine environment bioremediation and water treatment with microalgae technology

• Marine animal’s vaccine production for microalgae with synthetic biology platform

• Advanced photobioreactor systems for microalgae cultivation

• High density fermentation with marine microbes for healthy food

• Bio-conversion of organic wastes and wastewater to high valuable products

迟占有 教授

孔凡涛 副教授

王菁晗 讲师

主要成果：

在Trends in Biotechnology, Renewable & Sustainable Energy Reviews, Plant Cell，Biotechnology for Biofuels等权威杂志发表论文60余篇，被引用1000次以上，获得多项中国及国际专利授权。

Achievements:

This research group has published more than 60 peer-reviewed papers in high ranking journals such asTrends in Biotechnology, Renewable & Sustainable Energy Reviews, Plant Cell，andBiotechnology for Biofuels. They were cited for more than 1000 time. This group has many authorized patents in China, as well as USA and Japan.

1.迟占有，朱陈霸，朱贺，李佳琪，程龙艳，唐颖，微藻培养系统、腔体式光生物反应器及微藻培养方法技术方案，中国发明专利号：ZL201510902503.2.

2.Zhanyou Chi,Zhiyou Wen, Craig Frear, Shulin Chen,Heterotrophic algae high cell density production method and systems, US Patent # 7,989,195. Issued on August 2, 2011.

3.Ohama T, (*), Yamasaki T, Park H-S, Kong F, Hou L, ボツリオコッカスブラウニーの単細胞単離方法及び単細胞培養方法。授权日期： 2013.8.22, 授予国家：日本 (Japan)，专利号：WO2013121509 A1.

4.一种兼养微生物营养转化处理高氨氮废水的方法（专利号：ZL 2016 1 0091638.X，授权公告号：CN 105712490 B）.

1. Chenba Zhu, Xiaoqian Zhai, Yimei Xi, Jinghan Wang, Fantao Kong, Yunpeng Zhao,Zhanyou Chi*, Efficient CO₂capture from the air for high microalgal biomass production by a bicarbonate Pool, Journal of CO₂Utilization, 2020,37: 320 – 327

2. Zhanyou Chi, James O’Fallon, Shulin Chen.Bicarbonate Produced from Carbon Capture for Algae Culture.Trends in Biotechnology.2011, 29: 537-541

3. Zhanyou Chi,Yuxiao Xie, Farah Elloy, Yubin Zheng, Yucai Hu, Shulin Chen*,Bicarbonate-based Integrated Carbon Capture and Algae Production System with Extremely Alkalihalophilic Cyanobacterium.Bioresource Technology,2013, 133: 513–521

4. Chenba Zhu, Desen Han,Yonghai Li, Xiaoqian Zhai,Zhanyou Chi*，Yunpeng Zhao, Haibo Cai,Cultivation of aquaculture feedIsochrysis zhangjiangensisin low-cost wave driven floating photobioreactor without aeration device.Bioresource Technology,2019, 293 : 122018

5. Chenba Zhu,Zhanyou Chi,Chunwei Bi*, Yunpeng Zhao, Haibo Cai,Hydrodynamic performance of floating photobioreactors driven by wave energy,Biotechnology for Biofuels,2019,12:54

6. Kong F, Burlacot A, Liang Y, Légeret B, Alseekh S, Brotman Y, Fernie A, Krieger-Liszkay A, Beisson F, Peltier G, Li-Beisson Y. Interorganelle Communication: Peroxisomal MALATE DEHYDROGENASE2 Connects Lipid Catabolism to Photosynthesis through Redox Coupling in Chlamydomonas. (2018 August; (30):1824–1847) Plant Cell.

7. Kong F*, Yamaoka Y, Ohama T, Lee Y, Li-Beisson Y. Molecular Genetic Tools and Emerging Synthetic Biology Strategies to Increase Cellular Oil Content in Chlamydomonas reinhardtii. (2019 June; 60(6): 1184–1196) (*Corresponding author). Plant & Cell Physiology.

8. Wang, Jing-Han; Zhuang, Lin-Lan; Xu, Xue-Qiao; Deantes-Espinosa, Victor; Wang, Xiao-Xiong; Hu, Hong-Ying. Microalgal Attachment and Attached Systems for Biomass Production and Wastewater Treatment. Renewable & Sustainable Energy Reviews, 2018, 92C: 331-342.

9. Wang, Jinghan; Zhou, Wenguang; Yang, Haizhen; Wang, Feng; Ruan, Roger. Trophic Mode Conversion and Nitrogen Deprivation of Microalgae for High Ammonium Removal from Synthetic Wastewater. Bioresource Technology, 2015, 196(5): 668-676.

10. Chenba Zhu, Xiaoqian Zhai, Yimei Xi, Jinghan Wang, Fantao Kong, Yunpeng Zhao,Zhanyou Chi*,Floating photobioreactor for microalgae cultivation and application potential,World Journal of Microbiology and Biotechnology,2019, 35:190 (invited review)

11. Chenba Zhu, Ruolan Zhang, Longyan Cheng,Zhanyou Chi*,Recycling Culture ofNeochloris oleoabundansin Bicarbonate-based Integrated Carbon Capture and Algae Production System with Harvesting by Auto-flocculation,Biotechnology for Biofuels,2018, 11, 204

12. Zhanyou Chi, Marjorie Rover, Patrick Johnston, Robert C. Brown, Zhiyou Wen, Laura R. Jarboe*.Overliming Detoxification of Pyrolytic Sugars for Direct Fermentation of Levoglucosan to Ethanol.Bioresource Technology,2013, 150 : 220-227

13. Chenba Zhu, Xiaoqian Zhai, Jinghan Wang, Desen Han, Yonghai Li, Yimei Xi, Yajie Tang,Zhanyou Chi*,Large Scale Cultivation of Spirulina in a Floating Horizontal Photobioreactor without Aeration or an Agitation Device.Applied Microbiology and Biotechnology, 2018, 102: 8979-8987

14. Chenba Zhu, He Zhu, Longyan Cheng, Zhanyou Chi*,Bicarbonate-based carbon capture and algal production system on ocean with floating inflatable-membrane photobioreactor.Journal of Applied Phycology, 2018, 30(2)：875–885

15. Liang Y, Kong F, Romero IT, Burlacot A, CuinéS, Légeret B, Billon E, Brotman Y, Alseekh S, Fernie A, Beisson F, Peltier G, Li-Beisson Y. Branched-Chain Amino Acid Catabolism Impacts Triacylglycerol Homeostasis in Chlamydomonas reinhardtii. (2019 April;179(4):1502-1514) Plant Physiology.

16. Yamaoka Y, Shin S, Choi B, Kim H, Jang S, Yamano T, Kajikawa M, Kong F, Légeret B, Li-Beisson Y, Fukuzawa H, Lee Y. The bZIP1 Transcription Factor Regulates Lipid Remodeling and Contributes to ER Stress Management in Chlamydomonas reinhardtii. (2019 May;31(5):1127-1140) Plant Cell.

17. Kong F, Romero IT, Warakanont J, Li-Beisson Y. Lipid catabolism in microalgae. (2018 June; 218(4): 1340-1348) New Phytologist.

18. Kong F, Liang Y, Légeret B, Beyly-Adriano A, Blangy S, Haslam RP, Napier JA, Beisson F, Peltier G, Li-Beisson Y. Chlamydomonas carries out fatty acidβ-oxidation in ancestral peroxisomes using a bona fide acyl-CoA oxidase. (2017 April; 90(2):358-371) Plant Journal.

19. Wang, Jing-Han; Yang, Cheng; He, Lv-Qi-Shu; Dao, Guo-Hua; Du, Jing-Song; Han, Ya-Ping; Wu, Guang-Xue; Wu, Qian-Yuan; Hu, Hong-Ying. Meteorological factors and water quality changes of Plateau Lake Dianchi in China (1990–2015) and their joint influences on cyanobacterial blooms. Science of the Total Environment, 2019, 665: 406–418.

20. Wang, Jing-Han; Zhang, Tian-Yuan; Dao, Guo-Hua; Xu, Xue-Qiao; Wang, Xiao-Xiong; Hu, Hong-Ying. Microalgae-based Advanced Municipal Wastewater Treatment for Reuse in Water Bodies. Applied Microbiology and Biotechnology, 2017, 101(7): 2659-2675.

1.Laura Jarboe and Zhanyou Chi, Inhibition of microbial biocatalysts by biomass-derived aldehydes and methods for engineering tolerance, inNew Developments in Aldehydes Research, Nova Science Publishers, Inc. New York, 2013.

2.迟占有 赵春华，干细胞的体外大规模扩增，《干细胞原理技术与临床》赵春华，化学工业出版社，北京，2006.

迟占有 博士 教授

E-mail chizhy@

孔凡涛 博士 副教授

E-mail kongfantao@

王菁晗 博士 讲师

E-mail WangJinghan@