分子医学与药学研究室-大连理工大学生物工程学院（新）

基本信息

姓名：

伍会健

职称：

教授博士生导师

性别：

男

毕业院校：

九州大学（日本）

学位：

博士

在职信息：

在职

所在单位：

生物工程学院

所在单位：

生物工程学院

学科：

生物化学与分子生物学，细胞生物学，生药学

办公地点：

大连理工大学生物工程学院

联系方式：

0411-84706105

电子邮箱：

wuhj@dlut.edu.cn

科研团队

团队简介

课题组多年来主要从事恶性肿瘤发病机制研究，具体研究方向如下：

Ø蛋白质化学修饰与细胞的信号转导

Ø基因的转录调控与肿瘤发生

Ø肿瘤细胞侵袭转移发生机制

Ø周期节律失调与肿瘤发生发展间分子机制

先后承担国家973项目，863项目，自然科学基金等多个课题的研究工作，项目总经费1200多万元，近几年在国内外知名期刊共发表论文40余篇，包括Natrue系列期刊oncogene（肿瘤学TOP5期刊），Sci. Rep.，Cancer Letter, oncogenesis等；先后荣获国家自然科学二等奖，教育部自然科学一等奖，中华医学科技一等奖，辽宁省自然科学二等奖，辽宁省医学科技一等奖，大连市科技进步一等奖等多个奖项；组建了辽宁省“蛋白质修饰与疾病发生”重点实验室以及大连市“蛋白质修饰与肿瘤分子生物学”重点实验室。

代表性成果

一、论文

1.Huijian Wu, Yupeng Chen, Jing Liang, et al. Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis.Nature(2005)438: 981-987.

2.Wu H, Sun L, Zhang Y, Chen Y, Shi B, Li R, Wang Y, Liang J, Fan D, Wu G, Wang D, Li S, Shang Y. Coordinated regulation of AIB1 transcriptional activity by sumoylation and phosphorylation.J Biol Chem. 2006, 281(31):21848-56.

3.Li, Shujing，Wang, Miao，Ao, Xiang，Chang, K. Alan，Yang, Chunhua，Zhao, Feng，Bi, Hailian，Liu, Ying，Xiao, Liyun，Wu, Huijian(*)，CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha，Oncogene，2013，32（41）：4883-4891. (肿瘤学TOP期刊)

4.Bai, XY, Li, SJ, Wang, M, Li, XH, Yang, YY, Xu, ZW, Li, BW, Li, YN, Xia, KK, Chen, H.,Wu H(*).Kruppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion,CANCER LETTERS, 2018, 412: 224-235

5.Yang, Chunhua，Li, Shujing，Wang, Miao，Chang, Alan K.，Liu, Ying，Zhao, Feng，Xiao, Liyun，Han, Lin，Wang, Dao，Li, Shen，Wu, Huijian(*)，PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha，Molecular Cancer，2013，12：1-13

6.Zhao, Feng，Wang, Miao，Li, Shujing，Bai, Xiaoyan，Bi, Hailian，Liu, Ying，Ao, Xiang，Jia, Zhaojun，Wu, Huijian(*)，DACH1 inhibits SNAI1-mediated epithelial-mesenchymal transition and represses breast carcinoma metastasis，Oncogenesis，2015，4：e143。

二、获奖

1. 雌激素和三氧苯胺诱发妇科肿瘤的分子机制，国家自然科学二等奖，2008

2. 雌激素及其拮抗剂三氧苯胺诱发妇科肿瘤的分子机制研究，教育部自然科学一等奖，2008

3. 雌激素及其拮抗剂三氧苯胺诱发妇科肿瘤的分子机制研究，中华医学科技一等奖，2007

4. 肿瘤中AIB1、PTEN、Bcl-2等重要蛋白的分子调控机制，辽宁省自然科学二等奖，2014

5. SUMO化修饰在肿瘤发生、发展中的作用，辽宁省医学科技一等奖，2016

6. SUMO化修饰对乳腺癌细胞的分子调控机制，大连市科技进步一等奖，2012

专利情况

1.伍会健，邢欣荣，李淑晶，杨春华.一种蛇毒浮肿因子抑制蛋白的制备及其应用，专利号：ZL 2009 1 0012621.0，授权日期：2013.6.5。

2.伍会健，刘文栋，洪永德，过倩萍一种乳腺癌抑癌蛋白的鉴定和应用，200910220338.7，2009。

论文情况

1. Huijian Wu, Yupeng Chen, Jing Liang, et al. Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature (2005)438: 981-987.

2. Wu H, Sun L, Zhang Y, Chen Y, Shi B, Li R, Wang Y, Liang J, Fan D, Wu G, Wang D, Li S, Shang Y. Coordinated regulation of AIB1 transcriptional activity by sumoylation and phosphorylation. J Biol Chem. 2006, 281(31):21848-56.

3. Li, Shujing，Wang, Miao，Ao, Xiang，Chang, K. Alan，Yang, Chunhua，Zhao, Feng，Bi, Hailian，Liu, Ying，Xiao, Liyun，Wu, Huijian(*)，CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha，Oncogene，2013，32（41）：4883-4891

4. Bai, XY, Li, SJ, Wang, M, Li, XH, Yang, YY, Xu, ZW, Li, BW, Li, YN, Xia, KK, Chen, H., Wu H(*). Kruppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion, CANCER LETTERS, 2018, 412: 224-235

5. Yang, Chunhua，Li, Shujing，Wang, Miao，Chang, Alan K.，Liu, Ying，Zhao, Feng，Xiao, Liyun，Han, Lin，Wang, Dao，Li, Shen，Wu, Huijian(*)，PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha，Molecular Cancer，2013，12：1-13

6. Shujing Li, Jin Wang, Gaolei Hu, Sattout Aman, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Miao Wang, Huijian Wu(*). SUMOylation of MCL1 protein enhances its stability by regulating the ubiquitin-proteasome pathway. Cellular Signalling, 2020, 73:109686

7. Yangyang Yang, Xiahui Li, Bowen Li, Liying Mu, Jin Wang, Yunmeng Cheng, Yao Gu & Wu, Huijian(*). Associations between TNFSF4 gene polymorphisms (rs2205960 G > A, rs704840 T > G and rs844648 G > A) and susceptibility to autoimmune diseases in Asians: a meta-analysis, Immunological Investigations, 2020, 24:1-17.

8. Zhao Y, Chen K, Yildiz EA, Li S, Hou Y, Zhang X, Wang Z, Zhao J, Barbon A, Yaglioglu HG, Wu H(*). Efficient Intersystem Crossing in the Tröger's Base Derived From 4-Amino-1,8-naphthalimide and Application as a Potent Photodynamic Therapy Reagent, Chemistry. 2020

9. Jiang X, Bai XY, Li B, Li Y, Xia K, Wang M, Li S, Wu H(*). Plasma Inter-Alpha-Trypsin Inhibitor Heavy Chains H3 and H4 Serve as Novel Diagnostic Biomarkers in Human Colorectal Cancer. Dis Markers, 2019:5069614

10. Wang J, Li S, Li X, Li B, Li Y, Xia K, Yang Y, Aman S, Wang M, Wu H. Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expression. Cancer Cell Int. 2019, 19:182

11. Jia, Zhaojun; Wang, Miao; Li, Shujing; Li, Xiahui; Bai, Xiao-Yan; Xu, Zhaowei; Yang, Yangyang; Li, Bowen; Li, Yanan; Wu, Hujian(*). U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation, Cell death & disease, 2018, 9(2): 63

12. Sun, Dongsheng; Liu, Yang; Wang, Huihui; Deng, Fei; Zhang, Ying; Zhao, Shan; Ma, Xiaojun; Wu, Hujian(*); Sun, Guangwei. Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells, International journal of biological macromolecules, 2018, 109: 1154-1163

13. Zhaowei Xu, Yangyang Yang, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Xiahui Li, Miao Wang,Shujing Li, Huijian Wu(*). Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breastcancer cell proliferation via deacetylase SIRT1. Cell death & disease, 2018, 9:559

14. Huan Chen, Zhaowei Xu, Xiahui Li, Yangyang Yang, Bowen Li, Yanan Li, Kangkai Xia, Jian Wang, Shujing Li,Miao Wang, Huijian Wu(*). α-catenin SUMOylation increases IκBαstability and inhibits breast cancer progression, Oncogenesis, 2018, 7:28

15. Wang M, Yang Y, Xu J, Bai W, Ren X, Huijian Wu(*). CircRNAs as biomarkers of cancer: a meta-analysis. BMC Cancer. 2018, 18(1):303

16. Bi, Hailian，Li, Shujing，Qu, Xinjian，Wang, Miao，Bai, Xiaoyan，Xu, Zhaowei，Ao, Xiang，Jia, Zhaojun，Yang, Yangyang，Wu, Hujian(*)，DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase，Cell Death and Disease，2015，6：e1891。

17. Liu, Ying，Ao, Xiang，Jia, Zhaojun，Bai, Xiao-Yan，Xu, Zhaowei，Hu, Gaolei，Jiang, Xiao，Chen, Min，Wu, Huijian(*)，FOXK2 Transcription Factor Suppresses ER alpha-positive Breast Cancer Cell Growth Through Down-Regulating the Stability of ER alpha via mechanism involving BRCA1/BARD1，Scientific Reports，2015，5：8796。

18. Zhao, Feng，Wang, Miao，Li, Shujing，Bai, Xiaoyan，Bi, Hailian，Liu, Ying，Ao, Xiang，Jia, Zhaojun，Wu, Huijian(*)，DACH1 inhibits SNAI1-mediated epithelial-mesenchymal transition and represses breast carcinoma metastasis，Oncogenesis，2015，4：e143。

19. Bai, Xiao-Yan，Li, Shujing，Wang, Miao，Qu, Xinjian，Hu, Gaolei，Xu, Zhaowei，Chen, Min，He, Guo-Wei，Wu, Huijian(*)，Association of Monocyte Chemoattractant Protein-1 (MCP-1)-2518A > G Polymorphism with Susceptibility to Coronary Artery Disease: A Meta-Analysis，Annals of Human Genetics，2015，79（3）：173-187。

20. Ao, Xiang，Liu, Ying，Bai, Xiao-Yan，Qu, Xinjian，Xu, Zhaowei，Hu, Gaolei，Chen, Min，Wu, Huijian(*)，Association between EHBP1 rs721048(A > G) polymorphism and prostate cancer susceptibility: a meta-analysis of 17 studies involving 150,678 subjects，OncoTargets and Therapy，2015，8：1671-1680。

21. Bai, Xiao-Yan，Qu, Xinjian，Jiang, Xiao，Xu, Zhaowei，Yang, Yangyang，Su, Qiming，Wang, Miao，Wu, Huijian(*)，Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects，Journal of Cancer，2015，6（9）：913-921。

22. Zhao, Jianzhang(*)，Huang, Ling，Cui, Xiaoneng，Li, Shujing，Wu, Huijian(*)，Maximizing the thiol-activated photodynamic and fluorescence imaging functionalities of theranostic reagents by odularization of Bodipy-based dyad triplet photosensitizers，J. Mater. Chem. B，2015，3：9194-9211。

23. Ma, Caixia，Song, Yangiu，Xiao, Liyun，Xue, Lixiang，Li, Wenjuan，Laforest, Brigitte，Komati, Hiba，Wang, Weiping，Jia, Zhuqing，Zhou, Chunyan，Zou, Yunzeng，Nemer, Mona，Zhang, Shanfeng，Bai, Xiaowen，Wu, Huijian(*)，Zang, Mingxi(*)，EGF is required for cardiac differentiation of P19CL6 cells through interactionwith GATA-4 in a time- and dose-dependent manner，Cell. Mol. Life Sci.，2014，72：2005-2022。

24. Bi, Hailian，Li, Shujing，Wang, Miao，Jia, Zhaojun，Chang, Alan K.，Pang, Pengsha，Wu, Huijian(*)，SUMOylation of GPS2 protein regulates its transcription-suppressing function，Molecular Biology of the Cell，2014，25（16）：2499-2508。

25. Xiao, Liyun，Chang, Alan K，Zang, Ming-Xi，Bi, Hailian，Li, Shujing，Wang, Miao，Xing, Xinrong，Wu, Huijian(*)，Induction of the CLOCK gene by E2-ERalpha signaling promotes the proliferation of breast cancer cells，PLos One，2014，9（5）：e95878-e95878。

26. Cui, Xiaoneng，Zhao, Jianzhang(*)，Lou, Zhangrong，Li, Shujing，Wu, Huijian(*)，Han, Keli(*)，Switchingof the Triplet Excited State of Rhodamine/Naphthaleneimide Dyads: AnExperimental and Theoretical Study，J. Org. Chem.，2014，80：568-584。

27. Li, Shen，Zhang, Ying(*)，Chen, Li，Li, Na，Xie, Hongguo，Guo, Xin，Zhao, Shan，Yu, Weiting，Wu, Huijian(*)，Ma, Xiaojun，The relationship between the inflammatory response and cell adhesion onalginate-chitosan-alginate microcapsules after transplantation，J Biomed Mater Res A，2014，103：2333-2343。

28. Li, Shujing，Ao, Xiang，Wu, Huijian(*)，The role of circadian rhythm in breast cancer.，Chinese Journal of Cancer Research，2013，25（4）：442-450。

29. Xing, Xinrong，Bi, Hailian，Chang, Alan K.，Zang, Ming-Xi，Wang, Miao，Ao, Xiang，Li, Shen，Pan, Hongming，Guo, Qianping，Wu, Huijian(*)，SUMOyl

30. ation of AhR modulates its activity and stability through inhibiting its ubiquitination.，Journal of Cellular Physiology，2012，227（12）：3812-3819。

31. Chang, Alan K.，Wu, Huijian(*)，The role of AIB1 in breast cancer.，Oncology Letters，2012，4（4）：588-594。

32. Li, Shujing，Yang, Chunhua，Hong, Yongde，Bi, Hailian，Zhao, Feng，Liu, Ying，Ao, Xiang，Pang, Pengsha，Xing, Xinrong，Chang, Alan K.，Xiao, Liyun，Zhang, Yuanyuan，Wu, Huijian(*)，The transcriptional activity of co-activator AIB1 is regulated by the SUMO E3 Ligase PIAS1，Biology of the Cell，2012，104（5）：287-296。

33. Hong, Yongde，Xing, Xinrong，Li, Shujing，Bi, Hailian，Yang, Chunhua，Zhao, Feng，Liu, Ying，Ao, Xiang，Chang, Alan K.，Wu, Huijian(*)，SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.，PLos One，2011，6（8）：e23046-e23046。