本课题组长期致力于动物性食品安全保障技术的研究,重点研究开发绿色、无公害的抗生素替代品,如特异性卵黄免疫球蛋白、噬菌体和天然植物活性物质系列功效产品,为防控陆生及水生动物疾病并保障食品安全提供技术支持。
主要研究方向:
(1)特异性卵黄免疫球蛋白(IgY)替代抗生素的研究;
(2)噬菌体技术控制动物细菌性疾病的研究;
(3)微切变-助剂互作技术高效利用天然活性物质的研发;
(4)养殖业废弃物及染疫动物尸体无害化处理与资源化利用。
承担项目:国家自然科学基金委“杰出青年基金”、“重大国际合作项目”和“面上项目”,“十三五国家重点研发计划”、国家海洋公益项目、科技部863计划项目、国家发改委高新技术产业化示范项目等国家级以及省市项目等累计共20项,科研经费总额达到2000余万元。
1.特异性卵黄抗体替代抗生素防控动物疾病并保障食品安全,辽宁省科技进步奖,二等奖,2015
2.高效利用天然活性物质的微切变-助剂互作技术的研究与应用,辽宁省科技进步奖,二等奖,2014
3.特异性卵黄抗体替代抗生素防控动物疾病并保障食品安全,大连市科技进步奖,一等奖,2014
4.水貂高效健康养殖关键技术创新及产业化,大连市科技局,大连市科技进步奖,一等奖,2017
5.特异性卵黄抗体防控新疆垦区奶牛乳腺炎的关键技术与应用示范,八师石河子市科学技术进步奖,二等奖,2017
1.徐永平,徐乐,李晓宇,王丽丽,李淑英。抗黄海希瓦氏菌卵黄抗体及其制备方法。专利号:ZL201510642165.3
2.李晓宇,靖凯霖,徐永平,李媛,王丽丽。抗灿烂弧菌卵黄抗体及其制备方法。专利号:ZL201510641138.4
3.徐永平,王熙涛,续彦龙,龚改林,王丽丽,李晓宇,车鉴。复合微生物海藻肥的制备方法。专利号:ZL201510152232.3
4.徐永平,龚改林,王丽丽,续彦龙,王熙涛,李晓宇,李淑英。一种具有抗虫功能的生物有机肥及其制备方法。专利号:ZL201510002881.5
5.徐永平,李晶泉,李晓宇,李媛,王丽丽,李淑英。一种金黄色葡萄球菌特异性鸡卵黄免疫球蛋白可变区单链抗体及用途。专利号:ZL 201510413472.4
6.徐永平,车鉴,李淑英,李晓宇,王丽丽,王熙涛,张建成,阳桂菊。一株具有快速降解亚硝态氮功能和抑菌功能的侧孢短芽孢杆菌及其应用。专利号:ZL201510128510.1
7.徐永平,车鉴,李淑英,李晓宇,王丽丽,王熙涛,张建成,阳桂菊。一种海洋水产养殖用载体固定化抑菌型水质净化剂及其制备方法。专利号:ZL201510128508.4
8.徐永平,车鉴,李淑英,李晓宇,王丽丽,王熙涛,张建成,阳桂菊。一种海洋水产养殖用抑菌型水质净化剂及其制备方法。专利号:ZL201510128531.3
9.徐永平,曹振辉,张建城,李振,李晓宇,王丽丽,李纪彬,李淑英,徐乐。一种铜绿假单胞菌噬菌体及其在水貂出血性肺炎预防中的应用。专利号:ZL201410235510.7
10.徐永平,刘士茹,金礼吉,尤建嵩,李晓宇,王丽丽。一种犬自主采食型药物载体及其制备方法。专利号:ZL201310715097.X
11.徐永平,张建城,曹振辉,王丽丽,李振,徐乐。一种分离的溶藻弧菌噬菌体及其在海参疾病预防中的应用。专利号:ZL201410108994.9
12.徐永平,王熙涛,金礼吉,李晓宇,李建光,汪将,车鉴。刺参微生物脱胶海带发酵饲料及其制备方法。专利号:ZL201310683473.1
13.徐永平,吴琼,尤建嵩,金礼吉,李晓宇。一种毛皮动物药效营养膏及其制备方法。专利号: ZL 201310186117.9
14.徐永平,李建光,金礼吉,汪将,车鉴,蒲红宇。一种海参微生态水质调节剂及其制备方法。专利号: ZL 201210082156.X
15.徐永平,李建光,金礼吉,汪将,车鉴,蒲红宇,张恒慧。一种海参种参促熟饲料添加剂。专利号:ZL201110240441.5
16.徐永平,李建光,金礼吉,汪将,车鉴,蒲红宇,张恒慧.一种海参促熟饲料及其制备方法。专利号:ZL 201110240248.1
17.徐永平,李建光,金礼吉,李晶泉,蒲红宇。海参微生物发酵及其制备方法。专利号:ZL201110240617.7
18.徐永平,尤建嵩,金礼吉,李晓宇,马永生,王林会,李化强,吴菲菲。一种大肠杆菌多个肠毒素基因的融合体及其应用。专利号:ZL 201010236644.2
19.徐永平,张恒慧,金礼吉,尤建嵩,李晓宇。一种动物食疗性卵黄抗体提纯粉膏状制剂及其制备方法。专利号:ZL 201110209889.0
20.金礼吉,韩丽丽,徐永平,李晓宇,尤建嵩,王林会,邹栋梁,陆燕,续繁星,巨文娜,王妮。一种用于水果保鲜的特异性卵黄抗体制剂、制备方法及应用。专利号:ZL 200910010039.0
21.徐永平,马永生,金礼吉,李淑英,李晓宇,尤建嵩,曹振辉,谭德猛。一种噬菌体口服微球制剂及其制备方法。专利号:ZL 201110404475.3
22.徐永平,李建光,金礼吉,李晓宇,谭德猛,王黎,汪将,车鉴。一种环保型海参条索状饲料及其制备方法。专利号:ZL 201010227560.2
23.徐永平,孙永欣,刘钢,汪婷婷,金礼吉,姜志强。一种植物型刺参复方免疫促进剂。专利号:ZL 200710158203.3
24.徐永平,刘钢,孙永欣,金礼吉,薛继鹏,汪婷婷,王开来。一种皱纹盘鲍用复方中草药诱食及免疫增强剂。专利号:ZL 200710158205.2
25.徐永平。一种防治对虾病毒病的卵黄免疫球蛋白及其制备方法和应用。专利号:ZL 200410020691.8
1.Yuan Y., Qu K., Tan D., Li X., Wang L., Cong C., Xiu Z., Xu Y.* Isolation and characterization of a bacteriophage and its potential to disrupt multi-drug resistantPseudomonas aeruginosabiofilms. Microbial Pathogenesis, 2019, 128(1): 329-336.
2.Yuan Y., Wang L., Li X., Tan D., Cong C., Xu Y.* Efficacy of a phage cocktail in controlling phage resistance development in multidrug resistantAcinetobacter baumannii. Virus Research, 2019, 272(1): 197734.
3.Yuan Y., Zhao F., Wang L., Tan D., Cong C., Li X., Xu Y.*.Complete genome analyses of the novelEnterococcus faecalisphage vB_EfaS_AL3. Archives of Virology, 2019, 164(10): 2599-2603.
4.Ren H., Li Z., Xu Y., Wang L., Li X.*. Protective effectiveness of feeding phage cocktails in controllingVibrio parahaemolyticusinfection of sea cucumberApostichopus japonicus, Aquaculture, 2019, 503: 322-329.
5.Ren H., Li Z., Xu L., Li X., Wang L., Xu Y.* Genome sequence analysis ofVibrio parahaemolyticuslytic phage Vp_R1 with a C3 morphotype, Archives of Virology, 2019, 164: 2865-2871.
6.Xu L., Xu Y., He L., Zhang M., Wang L., Li Z., Li X.*Immunomodulatory effects of chicken egg yolk antibodies (IgY) against experimental Shewanella marisflavi AP629 infections in sea cucumbers (Apostichopus japonicus),Fish and Shellfish Immunology, 2019, 84: 108–119.
7.He D., Li X., Sai X., Wang L., Li S., Xu Y.*Camellia nitidissimaC.W. Chi: a review of botany, chemistry, and pharmacology. Phytochemistry Reviews, 2018, 17(2): 327-349.
8.He D., Zhang P., Sai X., Li X., Wang L., Xu Y.*Camellia euphlebiaflower extract inhibits oleic acid-induced lipid accumulation via reduction of lipogenesis in HepG2 cells. European Journal of Integrative Medicine, 2018, 17: 1-8.
9.He D., Sai X., Wang N., Li X., Wang L., Xu Y.*Camellia euphlebiaexerts its antidepressant-like effect via modulation of the hypothalamic-pituitary-adrenal axis and brain monoaminergic systems. Metabolic brain disease, 2018, 33(1): 301-312.
10.Pu H., Li X., Du Q., Cui H., Xu Y.*Research progress in the application of Chinese herbal medicines in aquaculture: a review. Engineering, 2017, 3(5): 731-737.
11.Wang L., Qu K., Li X., Cao Z., Wang X., Li Z., Song Y., Xu Y.*Use of bacteriophages to controlEscherichia coliO157:H7 in domestic ruminants, meat products, and fruits and vegetables. Foodborne Pathogens and Disease, 2017, 14(9): 483-493.
12.Wang X., Sun Y., Wang L., Li X., Qu K.,Xu Y.*Synbiotic dietary supplement affects growth, immune responses and intestinal microbiota ofApostichopus japonicas. Fish & Shellfish Immunology, 2017, 68: 232-242.
13.He D., Zhang P., Sai X., Li X., Wang L., Xu Y.*Hypolipidemic activity ofCamellia euphlebiaflower extract in high–fat-fed mice. Plant Foods for Human Nutrition, 2017, 72(4): 372-379.
14.Li Z., Song Y.X., Wang X.T., Zhang J.C., Li X.Y., Wang L.L., Xu Y.P.* Using phage PSM-1 to controlShewanella marisflaviinfection in Juvenile Sea Cucumber,Apostichopus japonicus. Journal of the World Aquaculture Society, 2017, 48(1): 113-121.
15.He D.Y.†, Wang L.L.†, Wang L.P., Li X.Y., Xu Y.P.*Spectroscopic studies on the interactions between novel bisnaphthalimide derivatives and calf thymus DNA. Journal of Photochemistry and Photobiology B: Biology. 2017, 166: 333–340.
徐永平 博士 教授
Prof. Yongping Xu
E-mail: xyping@
李晓宇 博士 副教授
Assoc. Prof. Xiaoyu Li
E-mail: xiaoyuli@
王丽丽 博士 副教授
Assoc. Prof. Lili Wang
E-mail: wanglili@